Flumethasone 21-pivalate

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Names

[ CAS No. ]:
2002-29-1

[ Name ]:
Flumethasone 21-pivalate

[Synonym ]:
MFCD00079287
Flumethasone pivalate
Flumethasone 21-Pivalate
[2-[(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate
EINECS 217-901-1

Chemical & Physical Properties

[ Density]:
1.27g/cm3

[ Boiling Point ]:
600.3ºC at 760mmHg

[ Molecular Formula ]:
C27H36F2O6

[ Molecular Weight ]:
494.56800

[ Flash Point ]:
316.8ºC

[ Exact Mass ]:
494.24800

[ PSA ]:
100.90000

[ LogP ]:
3.44070

[ Vapour Pressure ]:
6.51E-17mmHg at 25°C

[ Index of Refraction ]:
1.55

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU3832010
CHEMICAL NAME :
Pregna-1,4-diene-3,20-dione, 6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alpha- methyl-, 21-pivalate
CAS REGISTRY NUMBER :
2002-29-1
LAST UPDATED :
199710
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C27-H36-F2-O6
MOLECULAR WEIGHT :
494.63

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,705,1982

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S22-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TU3832010

Precursor & DownStream

Precursor

DownStream

  • Flumethasone

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Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.

Int. J. Pharm. 370(1-2) , 181-6, (2009)

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsio...

[Darkness effect in photochemotherapy. I. Effect of 8-methoxypsoralen on the epidermal patch test in allergic contact eczema].

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[Double-blind comparison of a betamethasone dipropionate-iodochloroxyquinoline combination and a flumethasone pivalate-iodochloroxyquinoline combination in the therapy of steroid-sensitive dermatoses with superinfection].

G. Ital. Dermatol. Venereol. 121(1) , XI-XIV, (1986)


More Articles

Related Compounds

  • Flumethasone 21-acetate
  • Tixocortol pivalate
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  • FluMethasone-17,20 21-Aldehyde
  • Flumethasone
  • Flumethasone Acid
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  • 2-{[6-(Fluoromethyl)pyrimidin-4-yl]amino}acetonitrile
  • 2-Mercaptobenzoyl azide
  • 1-[6-(2-Methoxyethyl)pyrimidin-4-yl]azetidin-3-ol
  • (2-{2-[2-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxymethyl)-benzene
  • 3,5-Dichloro-2-methylbenzodifluoride
  • Ethyl 2,5-dichloro-3-methylbenzoate
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