PTH-glycine

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Names

[ CAS No. ]:
2010-15-3

[ Name ]:
PTH-glycine

[Synonym ]:
3-phenyl-2-thio-hydantoi
3-(phenyl)-2-thioxo-4-imidazolidinone
3-PHENYL-2-THIOXO-4-IMIDAZOLIDINONE
3-Phenyl-2-thiohydantoin
3-phenyl-2-thioguidanthion
glycine,3-phenyl-2-thiohydantoin
EINECS 217-927-3
PHENYLTHIOHYDANTOIN-DL-GLYCINE
(E)-2-cyano-3-(4-fluorophenyl)prop-2-enethioamide
PHENYLTHIOHYDANTOIN-GLYCINE
1-phenyl-2-thiohydantoin
phenylthiohydantoin
3-phenyl-2-thioxotetrahydro-4H-imidazol-4-one
PTH-DL-GLYCINE
3-phenyl-2-thioxoimidazolidin-4-one
MFCD00027413

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Boiling Point ]:
292.1ºC at 760mmHg

[ Molecular Formula ]:
C9H8N2OS

[ Molecular Weight ]:
192.23800

[ Flash Point ]:
130.5ºC

[ Exact Mass ]:
192.03600

[ PSA ]:
64.43000

[ LogP ]:
1.30150

[ Index of Refraction ]:
1.684

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MU4025000
CHEMICAL NAME :
Hydantoin, 3-phenyl-2-thio-
CAS REGISTRY NUMBER :
2010-15-3
BEILSTEIN REFERENCE NO. :
0152535
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H8-N2-O-S
MOLECULAR WEIGHT :
192.25
WISWESSER LINE NOTATION :
T5MYNV EHJ BUS CR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
155 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930- Volume(issue)/page/year: 17(1),36,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
75 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD691-490

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331

[ Precautionary Statements ]:
P261-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
23/24/25

[ Safety Phrases ]:
S36/37/39-S45

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
MU4025000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • H-Gly-OMe.HCl
  • Phenyl isothiocyanate
  • METHYL DITHIOCARBANILATE
  • Glycine ethyl ester hydrochloride
  • Glycine
  • Glycine,N-[(phenylamino)thioxomethyl]-
  • ethyl 2-(phenylcarbamothioylamino)acetate
  • Methyl glycinate

DownStream

  • 1-Phenylimidazole
  • 5-benzylidene-3-phenyl-2-sulfanylideneimidazolidin-4-one
  • 5-amino-1-oxo-2,7-diphenyl-3-thioxo-2,3,7,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazole-6-carbonitrile
  • 2,4-Imidazolidinedione,3-phenyl-
  • 1-phenylimidazolidine-2,4,5-trione
  • 1-phenyl-3H-imidazo[2,1-b]quinazoline-2,5-dione

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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J. Steroid Biochem. Mol. Biol. 145 , 144-56, (2015)

Recently two drugs, namely the antiandrogen MDV-3100 and the inhibitor of 17α-hydroxylase abiraterone have been accepted by the FDA for the treatment of castration-resistant prostate cancer (CRPC) wit...


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Related Compounds

  • pTH (1-34) (rat)
  • pth-l-proline
  • pTH (3-34) (bovine)
  • pTH-Related Protein (1-16) (human, mouse, rat)
  • pTH-Related Protein (67-86) amide (human, bovine, dog, mouse, ovine, rat) trifluoroacetate salt
  • pTH (1-34) (bovine)
  • 2-{2-[4-(3-chlorophenyl)piperazin-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyridazin-3(2H)-one
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • 3-(Piperazin-1-ylmethyl)furan-2-carboxylicacid
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine