trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

Names

[ CAS No. ]:
201855-60-9

[ Name ]:
trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

[Synonym ]:
[(3S,4R)-1-Benzyl-4-(4-fluorophenyl)piperidin-3-yl]methanol
Paroxetine hydrochloride
[(3S,4R)-1-benzyl-4-(4-fluorophenyl)piperidin-3-yl]methanol

Chemical & Physical Properties

[ Density]:
1.139g/cm3

[ Boiling Point ]:
402.1ºC at 760 mmHg

[ Molecular Formula ]:
C19H22FNO

[ Molecular Weight ]:
299.38200

[ Flash Point ]:
197ºC

[ Exact Mass ]:
299.16900

[ PSA ]:
23.47000

[ LogP ]:
3.36160

[ Vapour Pressure ]:
3.45E-07mmHg at 25°C

[ Index of Refraction ]:
1.571

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (1R,3S)-4-CYCLOPENTENE-1,3-DIOL1-ACETATE
  • 4-Fluorophenylmagnesium chloride
  • (3R,7AS)-3-PHENYLTETRAHYDROPYRROLO[1,2-C]OXAZOL-5(3H)-ONE
  • isobutyl (3S,7aR)-5-oxo-3-phenyl-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazole-6-carboxylate
  • (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester
  • 3-(4-fluorophenyl)pent-4-enoic acid

DownStream

  • Paroxetine

Related Compounds

  • 2,2-Dichloro-1-(2-(trifluoromethoxy)phenyl)ethanol
  • (6-Amino-3-fluoro-2-methoxyphenyl)dimethylphosphine oxide
  • Ethyl 4-formyl-2,5-dimethylbenzoate
  • 4,5-Dichloro-2-fluoro-1,1'-biphenyl
  • 1-(Azetidin-3-yl)-5-bromo-3-nitro-1,2-dihydropyridin-2-one
  • 2,6-Dichloro-4-ethoxybenzoic acid
  • 4'-Methoxy-3'-(trifluoromethyl)phenacyl chloride
  • 2-[3-Chloro-5-(trifluoromethyl)phenyl]-2-methylpropanoic acid
  • 4-Bromo-3-(piperidin-3-yloxy)benzonitrile
  • 2-(1-Aminopropyl)-6-chloro-4-phenylphenol
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