trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

Names

[ CAS No. ]:
201855-60-9

[ Name ]:
trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol

[Synonym ]:
[(3S,4R)-1-Benzyl-4-(4-fluorophenyl)piperidin-3-yl]methanol
Paroxetine hydrochloride
[(3S,4R)-1-benzyl-4-(4-fluorophenyl)piperidin-3-yl]methanol

Chemical & Physical Properties

[ Density]:
1.139g/cm3

[ Boiling Point ]:
402.1ºC at 760 mmHg

[ Molecular Formula ]:
C19H22FNO

[ Molecular Weight ]:
299.38200

[ Flash Point ]:
197ºC

[ Exact Mass ]:
299.16900

[ PSA ]:
23.47000

[ LogP ]:
3.36160

[ Vapour Pressure ]:
3.45E-07mmHg at 25°C

[ Index of Refraction ]:
1.571

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (1R,3S)-4-CYCLOPENTENE-1,3-DIOL1-ACETATE
  • 4-Fluorophenylmagnesium chloride
  • (3R,7AS)-3-PHENYLTETRAHYDROPYRROLO[1,2-C]OXAZOL-5(3H)-ONE
  • isobutyl (3S,7aR)-5-oxo-3-phenyl-5,7a-dihydro-1H,3H-pyrrolo[1,2-c]oxazole-6-carboxylate
  • (3S,4R)-1-benzyl-4-(4-fluorophenyl)-2-oxopiperidine-3-carboxylic acid methyl ester
  • 3-(4-fluorophenyl)pent-4-enoic acid

DownStream

  • Paroxetine

Related Compounds

  • (2S)-1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)but-2-ynoyl]-2,3-dihydro-1H-indole-2-carboxylic acid
  • Tert-butyl 7-(3-bromopyridin-4-yl)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate
  • Tert-butyl 4-(4-bromo-1,3-thiazol-2-yl)-4-hydroxyazepane-1-carboxylate
  • tert-butyl 3-(4-bromo-1-methyl-1H-imidazol-2-yl)-3-hydroxyazetidine-1-carboxylate
  • Ethyl 1-(2-formylpyridin-4-yl)piperidine-3-carboxylate
  • 2-Methoxy-4-(3-methylideneazetidin-1-yl)-1,3-thiazole-5-carbaldehyde
  • 4-Chloro-6-(3-methylidenepyrrolidin-1-yl)pyrimidine-5-carbaldehyde
  • 2-(1-Hydroxypentyl)-1,3-thiazole-5-carbaldehyde
  • Ethyl 3-(3-amino-4-chlorophenyl)prop-2-ynoate
  • Methyl 6-[(2-methylbut-3-yn-2-yl)amino]pyrimidine-4-carboxylate
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