DEQUALINIUM IODIDE

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Names

[ CAS No. ]:
2019-42-3

[ Name ]:
DEQUALINIUM IODIDE

[Synonym ]:
1,1'-(Decane-1,10-diyl)bis(4-amino-2-methylquinolinium) diiodide
Quinaldinium,1,1'-decamethylenebis(4-amino-,diiodide
Dequalinium iodide
Dequalinium Diiodide
1,1'-Decamethylenebis(4-aminoquinaldinium iodide)
EINECS 217-964-5
Quinolinium,1,1'-(1,10-decanediyl)bis(4-amino-2-methyl-,diiodide
MFCD00191973

Chemical & Physical Properties

[ Melting Point ]:
>300ºC (dec.)(lit.)

[ Molecular Formula ]:
C₃₀H₄₀I₂N₄

[ Molecular Weight ]:
710.47400

[ Exact Mass ]:
710.13400

[ PSA ]:
59.80000

[ LogP ]:
1.34060

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VA0705000

CHEMICAL NAME :: Quinaldinium, 1,1'-decamethylenebis(4-amino-, diiodide

CAS REGISTRY NUMBER :: 2019-42-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C30-H40-N4.2I

MOLECULAR WEIGHT :: 710.54

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 8,110,1956

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
VA0705000

Articles

Antimicrobial topical agents used in the vagina.

Curr. Probl. Dermatol. 40 , 36-47, (2011)

Vaginally applied antimicrobial agents are widely used in the vagina in women with lower genital tract infections. An 'antimicrobial' is a general term that refers to a group of drugs that are effecti...

Dequalinium induces cytotoxicity in human leukemia NB4 cells by downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways and potentiation of specific inhibitors of these pathways.

Leuk. Res. 38(7) , 795-803, (2014)

Delocalized lipophilic cation dequalinium (DQA) selectively accumulates in mitochondria and displays anticancer activity in different malignancies. Our previous studies indicate a DQA-induced cytotoxi...

N-palmitoyl-ethanolamine (PEA) induces peripheral antinociceptive effect by ATP-sensitive K+-channel activation.

J. Pharmacol. Sci. 118(2) , 156-60, (2012)

Although the antinociceptive effects of N-palmitoyl-ethanolamine (PEA) were first characterized nearly 50 years ago, the identity of the mechanism that mediates these actions has not been elucidated. ...