Tenofovir Disoproxil Fumarate

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Names

[ CAS No. ]:
202138-50-9

[ Name ]:
Tenofovir Disoproxil Fumarate

[Synonym ]:
GS-4331-05
Viread (TN)
Tenofovir diisoproxil fuMarate
Carbonic acid, [[[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl][[[(1-methylethoxy)carbonyl]oxy]methoxy]phosphinyl]oxy]methyl 1-methylethyl ester, (2E)-2-butenedioate (1:1)
Tenofovir disoproxil fumarate
Bis(((isopropoxycarbonyl)oxy)methyl) (((1R)-2-(6-Amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonate (2E)-2-Butenedioate
acide (2E)-but-2-ènedioïque - {[(1R)-2-(6-amino-9H-purin-9-yl)-1-méthyléthoxy]méthyl}phosphonate de bis({[(1-méthyléthoxy)carbonyl]oxy}méthyle) (1:1)
Bis{[(isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate (1:1)
bis({[(propan-2-yloxy)carbonyl]oxy}methyl) ({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)phosphonate (2E)-but-2-enedioate (1:1)
Viread
bis({[(1-methylethoxy)carbonyl]oxy}methyl) {[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl}phosphonate (2E)-but-2-enedioate
Bis{[(isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate (2E)-2-butenedioate (1:1)
TENOFOVIR DISOPROXIC
Tenofovir DF
9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine Fumarate
Tenofovir (Disoproxil Fumarate)

Chemical & Physical Properties

[ Density]:
1.45 g/cm3

[ Boiling Point ]:
642.7ºC at 760 mmHg

[ Melting Point ]:
219ºC

[ Molecular Formula ]:
C23H34N5O14P

[ Molecular Weight ]:
635.515

[ Flash Point ]:
342.5ºC

[ Exact Mass ]:
635.183960

[ PSA ]:
269.85000

[ LogP ]:
3.32860

[ Vapour Pressure ]:
2.06E-16mmHg at 25°C

[ Storage condition ]:
Refrigerator

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chloromethyl isopropyl carbonate
  • fumaric acid
  • Tenofovir
  • tenofovir disoproxil chloromethyl-isopropyl carbonate
  • (R)-(+)-9-(2-Hydroxypropyl)Adenine
  • (R)-9-[2-(DIETHYLPHOSPHONOMETHOXY)PROPYL]ADENINE
  • 6H-Purin-6-imine, 1,7-dihydro- (9CI)

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Tenofovir Disoproxil Fumarate impurity N
  • Tenofovir disoproxil fumarate/emtricitabine
  • Tenofovir disoproxil
  • Tenofovir disoproxil aspartate
  • Tenofovir Disoproxil Isopropoxycarbonyl
  • tenofovir disoproxil chloromethyl-isopropyl carbonate