5-Flucytosine

Suppliers

Names

[ CAS No. ]:
2022-85-7

[ Name ]:
5-Flucytosine

[Synonym ]:
4-amino-5-fluoro-1,2-dihydropyrimidin-2-one
4-Amino-5-fluoro-2(1H)-pyrimidinone
5-Fluorocytosine
Fluocytosine
6-amino-5-fluoro-1H-pyrimidin-2-one
Flucytosin
Ancotil
4-amino-5-fluoro-2(1H)-pyrimidinone,5-Fluorocytosine,Flucytosine
5-Fluorocytosin
4-amino-5-fluoro-2(1H)-pyrimidinone,Flucytosine
MFCD00006035
4-Amino-5-fluoro-2-hydroxypyrimidine
EINECS 217-968-7
Fluorcytosine
Flucytosine
Ancobon
5-Fluorocystosine
4-amino-5-fluoro-2-pyrimidone
Fluorocytosine

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
298ºC

[ Melting Point ]:
298-300 °C (dec.)(lit.)

[ Molecular Formula ]:
C4H4FN3O

[ Molecular Weight ]:
129.092

[ Exact Mass ]:
129.033844

[ PSA ]:
71.77000

[ LogP ]:
-2.36

[ Vapour Pressure ]:
0.0492mmHg at 25°C

[ Index of Refraction ]:
1.649

[ Storage condition ]:
2-8°C

[ Stability ]:
Light Sensitive

[ Water Solubility ]:
1.5g/100mL (25 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA6040000
CHEMICAL NAME :
Cytosine, 5-fluoro-
CAS REGISTRY NUMBER :
2022-85-7
LAST UPDATED :
199801
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C4-H4-F-N3-O
MOLECULAR WEIGHT :
129.11
WISWESSER LINE NOTATION :
T6MVNJ DZ EF

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
1080 mg/kg/10D-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3811 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3336 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>600 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>15 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Yeast - Saccharomyces cerevisiae
DOSE/DURATION :
8 mg/L
REFERENCE :
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967- Volume(issue)/page/year: 146,253,1976 *** REVIEWS *** TOXICOLOGY REVIEW 32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975 Volume(issue)/page/year: -,49,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6122 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1033 (estimated) No. of Female Employees: 480 (estimated)

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H361

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R40

[ Safety Phrases ]:
S22-S24/25-S45-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
HA6040000

[ HS Code ]:
2933599090

Precursor & DownStream

Precursor

  • Pyrimidine, 4-chloro-2,5-difluoro
  • 2-ethylsulfanyl-5-fluoro-pyrimidin-4-ylamine
  • Dexelvucitabine

DownStream

  • 5-fluoro-N-trimethylsilyl-2-trimethylsilyloxypyrimidin-4-amine
  • Fluorouracil
  • Acetamide,N-(5-fluoro-2,3-dihydro-2-oxo-4-pyrimidinyl)-
  • 5-FLUORO-2-HYDROXYPYRIMIDINE
  • 2',3'-Di-O-acetyl-5'-deoxy-5-fluoro-D-cytidine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

The mannoprotein TIR3 (CAGL0C03872g) is required for sterol uptake in Candida glabrata.

Biochim. Biophys. Acta 1851(2) , 141-51, (2015)

Sterol uptake in the pathogenic fungus, Candida glabrata, occurs via the sterol transporter, CgAus1p. Azole inhibition of sterol biosynthesis can under certain circumstances be reversed by adding exog...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...


More Articles


Related Compounds

  • 5,8-difluoro-4-methyl-1,2,3,4-tetrahydronaphthalen-1-ol
  • 5-(2,4-difluorophenyl)-2-hydroxy-3-sulfooxybenzoic acid
  • 5-hydroxy-3-(methylamino)naphthalene-2,7-disulfonic acid
  • 5-methoxy-3-(di-n-propylamino)chroman
  • 5-(p-Toluenesulfonate)-2,3-O-isopropylidene-2-C-methyl-D-ribonic-gamma-lactone
  • 5-BROMO-2,3-DIHYDRO-1H-INDOLE HYDROCHLORIDE
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 1-(6-Aminobenzo[d]thiazol-2-yl)piperidin-4-ol
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide