AM281

Suppliers

Names

[ CAS No. ]:
202463-68-1

[ Name ]:
AM281

[Synonym ]:
AM 281
1H-Pyrazole-3-carboxamide, 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-4-morpholinyl-
Tocris-1115
S1595_Selleck
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(morpholin-4-yl)-1H-pyrazole-3-carboxamide
MFCD01861180
1-(2,4-Dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(4-morpholinyl)-1H-pyrazole-3-carboxamide

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Molecular Formula ]:
C₂₁H₁₉Cl₂IN₄O₂

[ Molecular Weight ]:
557.212

[ Exact Mass ]:
555.992981

[ PSA ]:
59.39000

[ LogP ]:
4.90

[ Index of Refraction ]:
1.706

[ Storage condition ]:
2-8C

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H315-H319-H335

[ Precautionary Statements ]:
P261-P264-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
26-36/37/39-45

[ RIDADR ]:
UN 2811 6

Articles

Cannabinoid agonists rearrange synaptic vesicles at excitatory synapses and depress motoneuron activity in vivo.

Neuropharmacology 92 , 69-79, (2015)

Impairment of motor skills is one of the most common acute adverse effects of cannabis. Related studies have focused mainly on psychomotor alterations, and little is known about the direct impact of c...

Activation of CB2 receptor is required for the therapeutic effect of ABHD6 inhibition in experimental autoimmune encephalomyelitis.

Neuropharmacology 99 , 196-209, (2015)

Alpha/beta-hydrolase domain 6 (ABHD6) is a novel 2-arachidonoylglycerol (2-AG) hydrolytic enzyme, that can fine-tune the endocannabinoid signaling in the central nervous system. Recently we and others...

Cannabinoid receptor 1 inhibition improves the intestinal microcirculation in experimental endotoxemia.

Clin. Hemorheol. Microcirc. 58(2) , 333-42, (2014)

Impairment of the intestinal microcirculation in endotoxemia may cause a deterioration of the mucosal barrier function thus releasing intraluminal bacteria and their toxins into the systemic circulati...

[1-(2,4-Dimethoxypyridin-3-yl)cyclopropyl]methanamine
2-(4-Methoxypyridin-2-yl)cyclopropan-1-amine
1-(5-Methoxy-2-nitrophenyl)cyclopropan-1-amine
[2,2-Dimethyl-3-(1-methylcyclopropyl)cyclopropyl]methanamine
5-(3-Fluoro-2-methylphenyl)-1,3-oxazol-2-amine
2-[1-(1,3-Thiazol-4-yl)cyclobutyl]ethan-1-amine
3,3-difluoro-1-(1H-pyrrol-2-yl)cyclobutan-1-amine
3-(4-Chloro-3-nitrophenyl)butan-1-amine
(2S)-5-phenylhexan-2-amine
rac-(1R,2R)-2-(1,3-dimethyl-1H-pyrazol-5-yl)cyclopropane-1-carboxylic acid

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.