4-Chloroaniline hydrochloride (1:1)

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Names

[ CAS No. ]:
20265-96-7

[ Name ]:
4-Chloroaniline hydrochloride (1:1)

[Synonym ]:
MFCD00042057
para-chloroaniline hydrochloride
EINECS 243-656-5
Benzenamine, 4-chloro-, hydrochloride (1:1)
4-Chloroaniline Hydrochloride
DSSTox_CID_296
4-Chlorobenzenamine hydrochloride
4-chloro-anilinehydrochloride
4-Chloroanilinium chloride
p-chloro-aniline hydrochloride
4-Chloroaniline HCl
4-chlorophenylaniline hydrochloride
4-Chloroaniline hydrochloride (1:1)
p-chloroaniline*HCl

Chemical & Physical Properties

[ Boiling Point ]:
232ºC at 760 mmHg

[ Melting Point ]:
230°C (subl.)

[ Molecular Formula ]:
C6H7Cl2N

[ Molecular Weight ]:
164.033

[ Flash Point ]:
89.5ºC

[ Exact Mass ]:
162.995560

[ PSA ]:
26.02000

[ LogP ]:
3.30540

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BX1394000
CHEMICAL NAME :
Aniline, p-chloro-, hydrochloride
CAS REGISTRY NUMBER :
20265-96-7
LAST UPDATED :
199701
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C6-H6-Cl-N.Cl-H
MOLECULAR WEIGHT :
164.04

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1200 mg/kg/16D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - changes in spleen
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5200 mg/kg/13W-I
TOXIC EFFECTS :
Cardiac - changes in heart weight Kidney, Ureter, Bladder - changes in bladder weight Blood - methemoglobinemia-carboxyhemoglobin
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1200 mg/kg/16D-I
TOXIC EFFECTS :
Liver - other changes Blood - changes in spleen Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1950 mg/kg/13W-I
TOXIC EFFECTS :
Blood - methemoglobinemia-carboxyhemoglobin Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
9270 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Endocrine - tumors Endocrine - adrenal cortex tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15450 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Endocrine - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
200 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-351,1989

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
S28-S36/37-S45-S60-S61

[ RIDADR ]:
2811

[ RTECS ]:
BX1394000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921440000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chloronitrobenzene
  • 4-Chloroaniline
  • 4-Chloroacetanilide
  • 2-Chloro-N-(4-chlorophenyl)acetamide
  • 9-Fluorenylmethyl N-p-chlorphenyl carbamate
  • N-(4-chlorophenyl)-8-(((4-chlorophenyl)imino)methyl)-3-methoxy-6,7-dihydro-5H-benzo[7]annulen-9-amine hydrochloride
  • 4-Bromochlorobenzene
  • 1-Butanesulfonylchloride, 1,1,2,2,3,3,4,4,4-nonafluoro-
  • 2,4-Dinitrochlorobenzene
  • N-((4-chlorophenyl)carbamoyl)-3-phenyl-3-thioxopropanethioamide

DownStream

  • Chlorhexidine
  • 4-CHLOROPHENYLTHIOUREA
  • Proguanil
  • Cycloguanil
  • Phosphorictriamide, N,N',N''-tris(4-chlorophenyl)-
  • 6-Chlorobenzothiazol-2-ylamine
  • 1-(4,6-Dimethylpyrimidine-2-yl)-3-(4-chlorophenyl)urea
  • N-(4-CHLOROPHENYL)-N-(4,6-DIMETHYLPYRIMIDIN-2-YL)GUANIDINE
  • 1-(4-CHLOROPHENYL)-1H-1,2,3-TRIAZOLE-4-CARBALDEHYDE
  • 2-Oxiranemethanamine,N-(4-chlorophenyl)-N-(2-oxiranylmethyl)-

Preparation


Customs

[ HS Code ]: 2921440000

[ Summary ]:
2921440000. diphenylamine and its derivatives; salts thereof. VAT:17.0%. Tax rebate rate:17.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 2-BROMO-5-CHLOROBENZENAMINE HYDROCHLORIDE
  • 4-Aminocyclohexanone hydrochloride (1:1)
  • 4-Oxoproline hydrochloride (1:1)
  • 4-Quinolinecarbonitrile hydrochloride (1:1)
  • 4-Chloronicotinaldehyde hydrochloride (1:1)
  • 4-Butylpiperidine hydrochloride (1:1)
  • 3-Bromo-7-methyl-2-(propan-2-yl)-4H,5H,6H,7H-pyrazolo[1,5-a]pyrimidine
  • 2-[3-(hydroxymethyl)pyrrolidin-1-yl]-N,N-dipropylacetamide
  • (1-(3-Phenoxypropyl)pyrrolidin-3-yl)methanol
  • 6-(2-Trifluoromethyl-phenyl)-pyridine-2,3-diamine
  • 2-[(1R)-1-Hydroxyethyl]benzonitrile
  • 9-Benzyl-1,4,9-triazaspiro[5.5]undecan-5-one
  • 2-(2-Fluorophenyl)-1-[3-(hydroxymethyl)pyrrolidin-1-yl]ethan-1-one
  • 1,3-Propanediamine, N3-cyclopropyl-N1-(3,5-dimethylphenyl)-N1-methyl-
  • 5,7-Dichloro-6-phenylpyrazolo[1,5-a]pyrimidine
  • (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)(3-(hydroxymethyl)pyrrolidin-1-yl)methanone
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