4H-pyrido[3,2-b][1,4]oxazin-3-one

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Names

[ CAS No. ]:
20348-09-8

[ Name ]:
4H-pyrido[3,2-b][1,4]oxazin-3-one

[Synonym ]:
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one
2H-Pyrido[4,3-b]-1,4-oxazin-3-(4H)-one
2H-Pyrido[3,2-b][1,4]oxazin-3(4H)-one
pyridoboxazinone
EINECS 243-751-1
MFCD00006697

Chemical & Physical Properties

[ Density]:
1.328g/cm3

[ Boiling Point ]:
384.159ºC at 760 mmHg

[ Melting Point ]:
204-206 °C(lit.)

[ Molecular Formula ]:
C7H6N2O2

[ Molecular Weight ]:
150.13500

[ Exact Mass ]:
150.04300

[ PSA ]:
51.22000

[ LogP ]:
0.55050

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.568

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2934999090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-(2-nitropyridin-3-yloxy)acetonitrile
  • 2-Amino-3-pyridinol
  • Chloroacetic acid
  • Chloroacetyl chloride
  • ethyl 2-bromoacetate
  • 6-bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
  • carbon monoxide
  • 2-Nitro-3-pyridinol
  • 2-(2-aminopyridin-3-yl)oxyacetonitrile

DownStream

  • 7-Bromo-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
  • 6-NITRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-3(4H)-ONE
  • 4-Allyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
  • 3,4-Dihydro-2H-pyrido[3,2-b][1,4]oxazine

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Synthesis and biological evaluation of oxadiazole derivatives as inhibitors of soluble guanylyl cyclase.

Bioorg. Med. Chem. 18(3) , 1288-96, (2010)

Soluble guanylyl cyclase (sGC) is an ubiquitously expressed enzyme that generates the second messenger cGMP and hence, leads to a number of physiological responses including vasodilation, inhibition o...


More Articles

Related Compounds

  • 6-nitro-4H-pyrido[3,2-b][1,4]oxazin-3-one
  • 7-bromo-4H-pyrido[3,2-b][1,4]oxazin-3-one
  • 4-allyl-4H-pyrido[3,2-b][1,4]oxazin-3-one
  • 6-bromo-4H-pyrido[3,2-b][1,4]oxazin-3-one
  • 6-amino-4H-pyrido[3,2-b][1,4]oxazin-3-one
  • 7-amino-4H-pyrido[3,2-b][1,4]oxazin-3-one
  • 1,1-Dimethylethyl N-[(4-Hydroxyphenyl)iminomethyl]carbamic Acid Ester
  • 5-{2-Azabicyclo[2.1.1]hexan-5-yl}-1,3-oxazole-4-carboxamide
  • 2-Amino-6-(4-(azepane-1-carbonyl)phenyl)pyrimidin-4(3H)-one
  • 6-Bromo-2-chloro-7-fluoroquinazolin-4-ol
  • 3,5-Dimethoxy-4-(1-methylcyclopropyl)benzoic acid
  • 3-Amino-5-(4-bromo-3,5-dimethoxyphenyl)-1H-pyrazole-4-carbonitrile
  • 3-Ethoxy-5-methoxy-4-methylbenzoic acid
  • 5-chloro-6-fluoro-3-isopropyl-1H-indole
  • Tert-butyl N-[1-(chlorosulfonyl)-4-methylpentan-2-YL]carbamate
  • 4-[(3-Bromo-2-methylphenyl)methoxy]-2-methoxybenzaldehyde
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