HA-1077 (hydrochloride)

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Names

[ CAS No. ]:
203911-27-7

[ Name ]:
HA-1077 (hydrochloride)

[Synonym ]:
HA-1077 (hydrochloride)
Fasudil dihydrochloride
5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline dihydrochloride hydrate
HA-1077 dihydrochloride
Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride, hydrate (1:2:1)
HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride,Fasudil dihydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C14H21Cl2N3O3S

[ Molecular Weight ]:
382.306

[ Exact Mass ]:
381.068054

[ PSA ]:
79.91000

[ LogP ]:
4.10600

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
HM4031166

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000

Articles

Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.

Br. J. Pharmacol. 98 , 1091, (1989)

The in vitro and in vivo vasorelaxant effects of HA1077, 1-(5-isoquinolinesulphonyl)-homopiperazine HCl, a novel vasodilator were examined. The inhibitory effects of HA1077 on contractile responses to...

A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture.

J. Pharmacol. Exp. Ther. 259 , 738, (1991)

The effects of a newly developed vasodilator agent, HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine hydrochloride], were investigated on the proliferation of cultured bovine aortic vascular smooth m...

Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.

Eur. J. Pharmacol. 195 , 267, (1991)

We examined the effects of HA1077, a potent inhibitor of protein kinases in vitro, on the relationship between tension and myosin-light chain (MLC20) phosphorylation in the initial phase of contractio...


More Articles

Related Compounds

  • Fasudil
  • HA-100 hydrochloride
  • HA-1004
  • HA peptide
  • 2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine,hydrochloride
  • 4-BENZENESULFONYLPIPERIDINE HYDROCHLORIDE
  • Methyl 2-(2-aminoethyl)-1-benzofuran-6-carboxylate
  • Methyl 6-aminobicyclo[3.2.0]heptane-3-carboxylate
  • (2R,3R)-2-(Difluoromethyl)-3,4-dihydro-2H-chromene-3-carboxylic acid
  • rac-(1R,3R,5R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)bicyclo[3.1.0]hexane-1-carboxylic acid
  • (1S,3R)-3-[(5-Methylpyridin-2-yl)amino]cyclopentane-1-carboxylic acid
  • rac-methyl (1R,5R)-6-hydroxybicyclo[3.2.0]heptane-3-carboxylate
  • Tert-butyl 2-(5-bromopyrimidin-2-yl)pyrrolidine-1-carboxylate
  • rac-2-[(3aR,6aR)-hexahydro-1H-furo[3,4-c]pyrrol-3a-yl]-5-methyl-1,3,4-oxadiazole
  • tert-butyl (2S)-2-[(1S)-1,2-dihydroxyethyl]morpholine-4-carboxylate
  • 5-(tert-Butoxycarbonyl)-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole-4-carboxylic acid
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