HA-1077 (hydrochloride)

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Names

[ CAS No. ]:
203911-27-7

[ Name ]:
HA-1077 (hydrochloride)

[Synonym ]:
HA-1077 (hydrochloride)
Fasudil dihydrochloride
5-(1,4-Diazepan-1-ylsulfonyl)isoquinoline dihydrochloride hydrate
HA-1077 dihydrochloride
Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride, hydrate (1:2:1)
HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride,Fasudil dihydrochloride

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₂₁Cl₂N₃O₃S

[ Molecular Weight ]:
382.306

[ Exact Mass ]:
381.068054

[ PSA ]:
79.91000

[ LogP ]:
4.10600

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
HM4031166

[ HS Code ]:
2942000000

Customs

[ HS Code ]: 2942000000

Articles

Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase.

Br. J. Pharmacol. 98 , 1091, (1989)

The in vitro and in vivo vasorelaxant effects of HA1077, 1-(5-isoquinolinesulphonyl)-homopiperazine HCl, a novel vasodilator were examined. The inhibitory effects of HA1077 on contractile responses to...

A new type of vasodilator, HA1077, an isoquinoline derivative, inhibits proliferation of bovine vascular smooth muscle cells in culture.

J. Pharmacol. Exp. Ther. 259 , 738, (1991)

The effects of a newly developed vasodilator agent, HA1077 [1-(5-isoquinolinesulfonyl)-homopiperazine hydrochloride], were investigated on the proliferation of cultured bovine aortic vascular smooth m...

Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle.

Eur. J. Pharmacol. 195 , 267, (1991)

We examined the effects of HA1077, a potent inhibitor of protein kinases in vitro, on the relationship between tension and myosin-light chain (MLC20) phosphorylation in the initial phase of contractio...

Fasudil
HA-100 hydrochloride
HA-1004
HA peptide
2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine,hydrochloride
4-BENZENESULFONYLPIPERIDINE HYDROCHLORIDE
2-ethyl-N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)butanamide
2-methyl-N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)benzamide
4-fluoro-N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)benzamide
2-chloro-N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)benzamide
2,4-dichloro-N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)benzamide
N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)-2-(trifluoromethyl)benzamide
N-[2-({6-[(6-methylpyridin-2-yl)amino]pyridazin-3-yl}amino)ethyl]thiophene-2-carboxamide
N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)cinnamamide
N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)benzo[d][1,3]dioxole-5-carboxamide
4-ethyl-N-(2-((6-((6-methylpyridin-2-yl)amino)pyridazin-3-yl)amino)ethyl)benzamide

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