(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride

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Names

[ CAS No. ]:
20445-33-4

[ Name ]:
(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride

[Synonym ]:
(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride
(2S)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride
MFCD00067105
(S)-(+)-Mosher's acid chloride
(S)-(+)-MTPA-Cl
(+)-1-methoxy-1-(trifluoromethyl)phenylacetyl chloride
(+)-MTPA-Cl
(S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoyl chloride
(+)-Moshers Acid Chloride
(+)-Mosher's Acid Chloride
Mosher's acid chloride
(+)-Mtpa chloride
(S)-(+)-α-Methoxy-α-t

Chemical & Physical Properties

[ Density]:
1.35 g/mL at 25 °C(lit.)

[ Boiling Point ]:
213-214 °C(lit.)

[ Molecular Formula ]:
C10H8ClF3O2

[ Molecular Weight ]:
252.61800

[ Flash Point ]:
194 °F

[ Exact Mass ]:
252.01600

[ PSA ]:
26.30000

[ LogP ]:
2.85600

[ Vapour Pressure ]:
0.164mmHg at 25°C

[ Index of Refraction ]:
n20/D 1.47(lit.)

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C

[ Risk Phrases ]:
R34:Causes burns.

[ Safety Phrases ]:
S26-S36/37/39-S45-S27

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Mosher's acid
  • (R)-(+)-Mosher's acid

DownStream

  • Chlorotributyltin
  • 2-(2,2-dimethylpropyl)pyridine
  • Cyclohexanol

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Six New Polyketide Decalin Compounds from Mangrove Endophytic Fungus Penicillium aurantiogriseum 328.

Mar. Drugs 13 , 6306-18, (2015)

Six new compounds with polyketide decalin ring, peaurantiogriseols A-F (1-6), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1- (1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,...

High-performance liquid chromatographic resolution of enantiomers of 1-phenyl-2-aminopropanes (amphetamines) with four chiral reagents.

J. Chromatogr. A. 307 , 335, (1984)

High-performance liquid chromatography (HPLC) was employed for resolution of enantiomers of chiral ring-substituted 1-phenyl-2- aminopropanes (amphetamines) and 1-phenylethylamine following derivatiza...

Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.

Nat. Protoc. 2 , 2451-2458, (2007)

This protocol details the most commonly used nuclear magnetic resonance (NMR)-based method for deducing the configuration of otherwise unknown stereogenic, secondary carbinol (alcohol) centers (R1R2CH...


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