4-Methyl-1,3-thiazole-5-carboxylic acid

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Names

[ CAS No. ]:
20485-41-0

[ Name ]:
4-Methyl-1,3-thiazole-5-carboxylic acid

[Synonym ]:
4-methyl-1,3-thiadiazole-5-carboxylic acid
4-Methyl-1H-thiazole-5-carboxylic acid
MFCD00626872
4-Methyl-thiazol-5-carbonsaeure
4-Methyl-5-thiazolecarboxylic acid
4-Methyl-1,3-thiazole-5-carboxylic acid
4-Methylthiazole-5-carboxylic acid
4-methylthiazole-5-carboxylicacid
5-Thiazolecarboxylic acid, 4-methyl-
4-Methyl-thiazole-5-carboxylic acid
5-Thiazolecarboxylic acid,4-methyl

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
303.6±22.0 °C at 760 mmHg

[ Melting Point ]:
287 °C (dec.)(lit.)

[ Molecular Formula ]:
C5H5NO2S

[ Molecular Weight ]:
143.164

[ Flash Point ]:
137.4±22.3 °C

[ Exact Mass ]:
143.004105

[ PSA ]:
78.43000

[ LogP ]:
0.58

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Storage condition ]:
Room temperature.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ3680000
CHEMICAL NAME :
5-Thiazolecarboxylic acid, 4-methyl-
CAS REGISTRY NUMBER :
20485-41-0
BEILSTEIN REFERENCE NO. :
0120745
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H5-N-O2-S
MOLECULAR WEIGHT :
143.17
WISWESSER LINE NOTATION :
T5N CSJ DVQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 26,497,1971

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H317

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XJ3680000

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl 4-methyl-5-thiazoleactate
  • (4-METHYLTHIAZOL-5-YL)METHANOL
  • Sulfurol
  • 5-Thiazolecarboxylicacid,2,3-dihydro-4-methyl-2-thioxo-
  • 4-methyl-thiazole-2,5-dicarboxylic acid diethyl ester

DownStream

  • 4-METHYL-1,3-THIAZOLE-5-CARBONYLCHLORIDE
  • (4-METHYLTHIAZOL-5-YL)METHANOL
  • 5-Formyl-4-methylthiazole
  • Methyl 4-methylthiazole-5-carboxylate
  • 4-Methylthiazole

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

  • 2-Iodo-4-methyl-1,3-thiazole-5-carboxylic acid
  • 2-Bromo-4-methyl-1,3-thiazole-5-carboxylic acid
  • 2-ethyl-4-methyl-1,3-thiazole-5-carboxylic acid
  • 2-Amino-4-methyl-1,3-thiazole-5-carboxylic acid
  • 2-benzyl-4-methyl-1,3-thiazole-5-carboxylic acid
  • 2-chloro-4-methyl-1,3-thiazole-5-carboxylic acid