Tubulysin A

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Names

[ CAS No. ]:
205304-86-5

[ Name ]:
Tubulysin A

[Synonym ]:
TubA
Tubulysin A

Chemical & Physical Properties

[ Molecular Formula ]:
C43H65N5O10S

[ Molecular Weight ]:
844.06900

[ Exact Mass ]:
843.44500

[ PSA ]:
239.99000

[ LogP ]:
7.06310

[ Appearance of Characters ]:
colorless or white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
organic solvents: soluble

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25-36/37/38

[ Safety Phrases ]:
36/37-45

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.

Mol. Biol. Cell 26 , 2769-87, (2015)

Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming pr...

Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

Biochem. J. 396 , 235-242, (2006)

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and an...

An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.

PLoS ONE 6 , e27249, (2011)

Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently,...


More Articles

Related Compounds

  • actinoplanone A
  • Thapsuine A
  • Apocynol A
  • (2S)-N-[(2S,5S,8S,11R,12S,15S,18S,21R)-5-[(3-bromo-4-methoxyphenyl)methyl]-2-[(2S)-butan-2-yl]-15-[3-(carbamoylamino)propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]-2-(butanoyla
  • Pseudoanguillosporin A
  • Digitoside A
  • 3-{[1-(2-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl}-1,3-diazaspiro[4.4]nonane-2,4-dione
  • 8-Azabicyclo[3.2.1]octane-2,3-diol, 8-methyl-, 2-acetate 3-benzoate, (exo,exo)-(+/-)-
  • 3-{[1-(4-fluorophenyl)-1H-1,2,3-triazol-4-yl]methyl}-1,3-diazaspiro[4.4]nonane-2,4-dione
  • 2-Chloro-4-[[4-oxo-2-(phenylamino)-5(4H)-thiazolylidene]methyl]phenyl 4-methoxybenzoate
  • 1-Piperidinecarboxylic acid, 2-[[(4-fluorophenyl)thio]methyl]-, 1,1-dimethylethyl ester
  • Carbamic acid, [3-hydroxy-1-[4-(methylthio)phenyl]propyl]-, 9H-fluoren-9-ylmethyl ester
  • [1-(Thiophen-3-yl)cyclopropyl]methanol
  • 1-(But-3-en-1-yl)-4-(3-chloro-2-methylphenyl)-1,2,3,4-tetrahydropyrazine-2,3-dione
  • 4-(Fluorosulfonyl)phenyl propanoate
  • 4-[3-[2-(3-Aminopropoxy)ethoxy]propylamino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
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