Tubulysin A

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Names

[ CAS No. ]:
205304-86-5

[ Name ]:
Tubulysin A

[Synonym ]:
TubA
Tubulysin A

Chemical & Physical Properties

[ Molecular Formula ]:
C₄₃H₆₅N₅O₁₀S

[ Molecular Weight ]:
844.06900

[ Exact Mass ]:
843.44500

[ PSA ]:
239.99000

[ LogP ]:
7.06310

[ Appearance of Characters ]:
colorless or white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
organic solvents: soluble

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25-36/37/38

[ Safety Phrases ]:
36/37-45

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.

Mol. Biol. Cell 26 , 2769-87, (2015)

Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming pr...

Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

Biochem. J. 396 , 235-242, (2006)

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and an...

An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.

PLoS ONE 6 , e27249, (2011)

Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently,...

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