Tubulysin A

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Names

[ CAS No. ]:
205304-86-5

[ Name ]:
Tubulysin A

[Synonym ]:
TubA
Tubulysin A

Chemical & Physical Properties

[ Molecular Formula ]:
C43H65N5O10S

[ Molecular Weight ]:
844.06900

[ Exact Mass ]:
843.44500

[ PSA ]:
239.99000

[ LogP ]:
7.06310

[ Appearance of Characters ]:
colorless or white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
organic solvents: soluble

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25-36/37/38

[ Safety Phrases ]:
36/37-45

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.

Mol. Biol. Cell 26 , 2769-87, (2015)

Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming pr...

Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

Biochem. J. 396 , 235-242, (2006)

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and an...

An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.

PLoS ONE 6 , e27249, (2011)

Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently,...


More Articles

Related Compounds

  • actinoplanone A
  • Thapsuine A
  • Apocynol A
  • (2S)-N-[(2S,5S,8S,11R,12S,15S,18S,21R)-5-[(3-bromo-4-methoxyphenyl)methyl]-2-[(2S)-butan-2-yl]-15-[3-(carbamoylamino)propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]-2-(butanoyla
  • Pseudoanguillosporin A
  • Digitoside A
  • Methyl 4-(((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)carbamoyl)benzoate
  • N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)benzo[c][1,2,5]thiadiazole-5-carboxamide
  • 3,5-dimethoxy-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)benzamide
  • 2,3-dimethoxy-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)benzamide
  • 1-(4-(difluoromethoxy)phenyl)-2-((4-fluorobenzyl)thio)-5-(4-methoxyphenyl)-1H-imidazole
  • 2,6-dimethoxy-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)benzamide
  • 2-(2-methoxyphenoxy)-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)acetamide
  • 2-(benzylthio)-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)acetamide
  • 3-(phenylthio)-N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)propanamide
  • N-((1-(pyrimidin-2-yl)piperidin-4-yl)methyl)-3-(trifluoromethyl)benzamide
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