Tubulysin A

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Names

[ CAS No. ]:
205304-86-5

[ Name ]:
Tubulysin A

[Synonym ]:
TubA
Tubulysin A

Chemical & Physical Properties

[ Molecular Formula ]:
C43H65N5O10S

[ Molecular Weight ]:
844.06900

[ Exact Mass ]:
843.44500

[ PSA ]:
239.99000

[ LogP ]:
7.06310

[ Appearance of Characters ]:
colorless or white

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
organic solvents: soluble

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
23/24/25-36/37/38

[ Safety Phrases ]:
36/37-45

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

A complex of ZO-1 and the BAR-domain protein TOCA-1 regulates actin assembly at the tight junction.

Mol. Biol. Cell 26 , 2769-87, (2015)

Assembly and sealing of the tight junction barrier are critically dependent on the perijunctional actin cytoskeleton, yet little is known about physical and functional links between barrier-forming pr...

Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

Biochem. J. 396 , 235-242, (2006)

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and an...

An antibody to de-N-acetyl sialic acid containing-polysialic acid identifies an intracellular antigen and induces apoptosis in human cancer cell lines.

PLoS ONE 6 , e27249, (2011)

Polysialic acid (PSA), an α2,8-linked homopolymer of N-acetylneuraminic acid (Neu5Ac), is developmentally regulated and its expression is thought to be restricted to a few tissues in adults. Recently,...


More Articles

Related Compounds

  • actinoplanone A
  • Thapsuine A
  • Apocynol A
  • (2S)-N-[(2S,5S,8S,11R,12S,15S,18S,21R)-5-[(3-bromo-4-methoxyphenyl)methyl]-2-[(2S)-butan-2-yl]-15-[3-(carbamoylamino)propyl]-21-hydroxy-4,11-dimethyl-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]-2-(butanoyla
  • Pseudoanguillosporin A
  • Digitoside A
  • N-cyclopropyl-4-({[(oxolan-2-yl)methyl]carbamoyl}methyl)morpholine-2-carboxamide
  • N-[(oxolan-2-yl)methyl]-2-[2-(pyrrolidine-1-carbonyl)morpholin-4-yl]acetamide
  • 3-[({2-tert-butylimidazo[1,2-b]pyridazin-6-yl}oxy)methyl]-1-{1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl}pyrrolidine
  • 2-[2-(4,4-difluoropiperidine-1-carbonyl)morpholin-4-yl]-N-[(furan-2-yl)methyl]acetamide
  • N-[(furan-2-yl)methyl]-2-[2-(morpholine-4-carbonyl)morpholin-4-yl]acetamide
  • 6-{4-[4-(pyridin-4-yl)pyrimidin-2-yl]piperazin-1-yl}-9H-purine
  • 2-{3-[({2-Tert-butylimidazo[1,2-b]pyridazin-6-yl}oxy)methyl]pyrrolidin-1-yl}-3-methyl-3,4-dihydroquinazolin-4-one
  • 6-methyl-3-(2-oxo-2-{6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridin-7-yl}ethyl)-3,4-dihydropyrimidin-4-one
  • 2-[3-(thiomorpholine-4-carbonyl)piperidin-1-yl]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 4-{3-bromo-6H,7H,8H,9H-pyrido[2,3-b]1,6-naphthyridine-7-carbonyl}-1-methyl-1H-1,2,3-triazole
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