Parthenolide

Suppliers

Names

[ CAS No. ]:
20554-84-1

[ Name ]:
Parthenolide

[Synonym ]:
Oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one, 2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-8-methylene-, (4Z)-
4,5α-Epoxy-6β-hydroxygermacra-1(10),11(13)-dien-12-oic Acid γ-Lactone
PartheNAlide
MFCD00134592
(4Z)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
Parthenolide
Parthelide
PARTHENOLIDE,TANACETUM PARTHENIUM

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
394.1±42.0 °C at 760 mmHg

[ Melting Point ]:
115-116ºC(lit.)

[ Molecular Formula ]:
C₁₅H₂₀O₃

[ Molecular Weight ]:
248.318

[ Flash Point ]:
166.3±22.5 °C

[ Exact Mass ]:
248.141251

[ PSA ]:
38.83000

[ LogP ]:
2.42

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.533

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LY4220000

CHEMICAL NAME :: Germacra-1(10),11(13)-dien-12-oic acid, 4,5-alpha-epoxy-6-beta-hydroxy-, gamma-lactone

CAS REGISTRY NUMBER :: 20554-84-1

LAST UPDATED :: 198512

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H20-O3

MOLECULAR WEIGHT :: 248.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Human HeLa cell

DOSE/DURATION :: 202 umol/L

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 30,3005,1981

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R11

[ Safety Phrases ]:
22-24/25-45-36/37/39-26-16

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LY4220000

[ HS Code ]:
29322090

Preparation

Articles

Distinct phenotypes of human prostate cancer cells associate with different adaptation to hypoxia and pro-inflammatory gene expression.

PLoS ONE 9(5) , e96250, (2014)

Hypoxia and inflammation are strictly interconnected both concurring to prostate cancer progression. Numerous reports highlight the role of tumor cells in the synthesis of pro-inflammatory molecules a...

Rapid evaluation and comparison of natural products and antioxidant activity in calendula, feverfew, and German chamomile extracts.

J. Chromatogr. A. 1385 , 103-10, (2015)

The present study describes a simple high performance thin layer chromatographic (HPTLC) method for the simultaneous quantification of apigenin, chamazulene, bisabolol and the use of DPPH free radical...

Secoiridoid glycosides from the root of Gentiana crassicaulis with inhibitory effects against LPS-induced NO and IL-6 production in RAW264 macrophages.

J. Nat. Med. 69 , 366-74, (2015)

The root of Gentiana crassicaulis has been widely used for the treatment of rheumatism, arthralgia, apoplexy, jaundice and diabetes in traditional medicines, and contains secoiridoid glycosides as the...