8-Hydroxy-efavirenz

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Names

[ CAS No. ]:
205754-33-2

[ Name ]:
8-Hydroxy-efavirenz

[Synonym ]:
8-HYDROXY EFAVIRENZ
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-
6-Chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(S)-6-chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
373.6±42.0 °C at 760 mmHg

[ Melting Point ]:
144-154ºC

[ Molecular Formula ]:
C14H9ClF3NO3

[ Molecular Weight ]:
331.674

[ Flash Point ]:
179.7±27.9 °C

[ Exact Mass ]:
331.022308

[ PSA ]:
58.56000

[ LogP ]:
4.80

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.608

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Efavirenz
  • 2-nitro-5-chloroanisole
  • 4-chloro-o-anisidine
  • N-(4-CHLORO-6-METHOXYPHENYL)-2,2-DIMETHYLPROPANAMIDE
  • 4-CHLORO-2-TRIFLUOROACETYL-6-METHOXYANILINE
  • 4-CHLORO-2-TRIFLUOROACETYL-6-(TERT-BUTYLDIMETHYLSILYLOXY)ANILINE

DownStream

Related Compounds

  • ent-8-Hydroxy Efavirenz
  • rac 8-Hydroxy Efavirenz
  • rac 8-Hydroxy Efavirenz-d4
  • (4S)-6-chloro-8-hydroxy-4-[2-(2,2,3,3-tetradeuteriocyclopropyl)ethynyl]-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
  • 8-(tert-Butyldimethylsilyloxy) 8-Hydroxy Efavirenz-d4
  • 8-Hydroxy Amoxapine (8-Hydroxyamoxapin)