Tacrine hydrochloride hydrate

Suppliers

Names

[ CAS No. ]:
206658-92-6

[ Name ]:
Tacrine hydrochloride hydrate

[Synonym ]:
1,2,3,4-Tetrahydroacridin-9-amine hydrochloride hydrate
1,2,3,4-Tetrahydro-9-acridinamine hydrochloride hydrate
9-Acridinamine, 1,2,3,4-tetrahydro-, hydrochloride, hydrate (1:1:1)
Tacrine hydrochloride hydrate

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₁₇ClN₂O

[ Molecular Weight ]:
252.740

[ Exact Mass ]:
252.102936

[ Storage condition ]:
-20℃

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H315-H319-H331-H335-H351

[ Precautionary Statements ]:
P261-P280-P301 + P310-P305 + P351 + P338-P311

[ RIDADR ]:
UN 2811 6.1 / PGIII

Articles

Synthesis, biological activity, and biopharmaceutical characterization of tacrine dimers as acetylcholinesterase inhibitors.

Int. J. Pharm. 477(1-2) , 442-53, (2014)

Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's disease (AD), has been extensively investigated in last seven decades. After dimerization o...

Influence of electronic and formulation variables on transdermal iontophoresis of tacrine hydrochloride.

Pharm. Dev. Technol. 20 , 442-57, (2015)

Freshly excised rat skin and side-by-side permeation cells were used to study the effect of electronic and formulation variables on transdermal iontophoretic delivery of tacrine. Current strength at 0...

Tacrine sinusoidal uptake and biliary excretion in sandwich-cultured primary rat hepatocytes.

J. Pharm. Pharm. Sci. 17(3) , 427-38, (2014)

PURPOSE. The knowledge of hepatic disposition kinetics of tacrine, a first cholinesterase inhibitor was approved by FDA for the treatment of Alzheimer's disease (AD), would help to understand its hepa...