2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine

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Names

[ CAS No. ]:
2076-70-2

[ Name ]:
2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine

[Synonym ]:
Imidazo(1,2-a)pyridine,2-(p-methylthiophenyl)
2-(p-Methylthiophenyl)imidazo(1,2-a)pyridine
2-<4-Methylmercapto-phenyl>-imidazo<1,2-a>pyridin
2-(4-(methylthio)phenyl)imidazo[1,2-a]pyridine
2-(4-methylsulfanyl-phenyl)-imidazo[1,2-a]pyridine

Chemical & Physical Properties

[ Density]:
1.19g/cm3

[ Molecular Formula ]:
C14H12N2S

[ Molecular Weight ]:
240.32300

[ Exact Mass ]:
240.07200

[ PSA ]:
42.60000

[ LogP ]:
3.72320

[ Index of Refraction ]:
1.655

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NJ5768000
CHEMICAL NAME :
Imidazo(1,2-a)pyridine, 2-(p-methylthiophenyl)-
CAS REGISTRY NUMBER :
2076-70-2
BEILSTEIN REFERENCE NO. :
0648329
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C14-H12-N2-S
MOLECULAR WEIGHT :
240.34
WISWESSER LINE NOTATION :
T56 AN DNJ CR DS1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 8,305,1965

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Aminopyridine
  • BENZENE, 1-ETHYNYL-4-(METHYLTHIO)-
  • 4-(Methylthio)acetophenone
  • 4-METHYLTHIO-BETA-NITROSTYRENE, >95
  • nitromethane
  • 4-(Methylthio)benzaldehyde
  • Thioanisole

DownStream

  • 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

Related Compounds

  • 2-p-Tolyl-imidazo[1,2-a]pyridine-8-carboxylic acid
  • 2-p-Tolyl-imidazo[1,2-a]pyridine
  • 2-[p-(Methylsulfonyl)phenyl]imidazo[1,2-a]pyridine-3-acetamide
  • 2-(p-Methoxyphenyl)-3-(morpholinomethyl)imidazo[1,2-a]pyridine
  • 2-(p-Nitrophenyl)-3-(piperidinomethyl)imidazo[1,2-a]pyridine
  • 3-(Morpholinomethyl)-2-(p-tolyl)imidazo[1,2-a]pyridine
  • 6-Bromo-5-(difluoromethyl)-3-methoxypyridine-2-sulfonamide
  • 2-(2,6-Diamino-4-(difluoromethyl)pyridin-3-yl)acetic acid
  • 3-(Difluoromethyl)-4-fluoro-6-methoxypyridin-2-amine
  • 2-Chloro-5-(difluoromethyl)-6-(trifluoromethyl)nicotinonitrile
  • 2-(Difluoromethyl)-6-iodo-4-methoxypyridine
  • 4-(Difluoromethyl)-3-methoxy-5-nitropicolinonitrile
  • 2-Chloro-5-(chloromethyl)-4-(difluoromethyl)-3-iodopyridine
  • 2-Chlorobenzo[d]oxazole-6-sulfonamide
  • (2,6-Dichloro-4-(difluoromethyl)pyridin-3-yl)methanol
  • 2-Chloro-5-(difluoromethyl)-4-fluoropyridin-3-ol