(S)-Styrene oxide

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Names

[ CAS No. ]:
20780-54-5

[ Name ]:
(S)-Styrene oxide

[Synonym ]:
(S)-(-)-Styrene oxide
(S)-(-)-Phenylethylene oxide
(S)-2-Phenyl-oxirane
MFCD00064310
(S)-2-Phenyloxirane
(2S)-2-Phenyloxirane
(S)-Phenylethylene oxide
(S)-(-)-Phenyloxirane
Oxirane, 2-phenyl-, (2S)-
S-Phenyloxirane
(S)-(−)-Phenyloxirane
(S)-Styrene oxide
(S)-(−)-Styrene oxide
Benzene, (epoxyethyl)-, (S)-

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
193.9±9.0 °C at 760 mmHg

[ Molecular Formula ]:
C₈H₈O

[ Molecular Weight ]:
120.148

[ Flash Point ]:
79.4±0.0 °C

[ Exact Mass ]:
120.057518

[ PSA ]:
12.53000

[ LogP ]:
1.61

[ Vapour Pressure ]:
0.6±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
2~8℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CZ9625030

CHEMICAL NAME :: Benzene, (epoxyethyl)-, (S)-

CAS REGISTRY NUMBER :: 20780-54-5

LAST UPDATED :: 199506

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C8-H8-O

MOLECULAR WEIGHT :: 120.16

WISWESSER LINE NOTATION :: T3OTJ BR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 125 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 278,289,1992

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H311-H315-H319-H331-H350

[ Precautionary Statements ]:
P201-P261-P280-P305 + P351 + P338-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R45;R20/21;R36/38

[ Safety Phrases ]:
S53-S26-S36/37-S45

[ RIDADR ]:
UN 2810 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
CZ9625030

[ HS Code ]:
2910900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(S)-(+)-1-PHENYL-1,2-ETHANEDIOL 2-TOSYLATE
2-Chloroacetophenone
phenylene-ethylene
(S)-2-BROMOSUCCINICACID
Styrene oxide
trimethyl[(2R,3S)-3-phenyloxiran-2-yl]silane
2-Bromoacetophenone
(S)-1-acetoxy-1-phenyl-2-chloroethane
alpha-(bromomethyl)benzyl alcohol
Benzaldehyde

DownStream

(R)-(-)-2-Methoxy-2-phenylethanol
(2S)-2-methoxy-2-phenylethanol
styrene glycol
phenyl propanol
2-Phenyl-1-propanol
Phenethyl alcohol
(±)-1-phenylethanol
(R)-1-Phenyl-1,2-ethanediol
styrene glycol
L-Phenylglycinol

Preparation

Customs

[ HS Code ]: 2910900090

[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

Articles

Cloning and characterization of an epoxide hydrolase from Cupriavidus metallidurans-CH34.

Protein Expr. Purif. 79(1) , 49-59, (2011)

A putative epoxide hydrolase-encoding gene was identified from the genome sequence of Cupriavidus metallidurans CH34. The gene was cloned and overexpressed in Escherichia coli with His(6)-tag at its N...

Simultaneous determination of aromatic acid metabolites of styrene and styrene-oxide in rat urine by gas chromatography-flame ionization detection.

J. Anal. Toxicol. 36(5) , 312-8, (2012)

A convenient and reliable gas chromatographic method was developed for the simultaneous determination of six aromatic acid metabolites of styrene and styrene-oxide in rat urine; i.e., benzoic (BA), ph...

Solvent and TMEDA effects on the configurational stability of chiral lithiated aryloxiranes.

Chemistry 17(29) , 8216-25, (2011)

The employment of hexane/N,N,N',N'-tetramethylethylenediamine (TMEDA) dramatically hinders the racemization of those lithiated styrene oxides (trifluoromethyl-, chloro-, and phenylthio-substituted) th...