17-ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE OXIME

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Names

[ CAS No. ]:
20799-24-0

[ Name ]:
17-ALPHA-ETHYNYL-19-NORTESTOSTERONE ACETATE OXIME

[Synonym ]:
Norethisterone acetate oxime
Norethisterone-3-oxime acetate
ORF 5263
Norethisterone acetate-3-oxime
So-36
Norethisterone oxime acetate
17alpha-Ethynyl-17beta-acetoxy-19-norandrost-4-en-3-one oxime

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
486.1ºC at 760mmHg

[ Molecular Formula ]:
C₂₂H₂₉NO₃

[ Molecular Weight ]:
355.47100

[ Flash Point ]:
247.8ºC

[ Exact Mass ]:
355.21500

[ PSA ]:
58.89000

[ LogP ]:
4.32440

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.618

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC8965500

CHEMICAL NAME :: 19-Norpregn-4-en-20-yn-3-one, 17-(acetyloxy)-, 3-oxime, (17-alpha)-

CAS REGISTRY NUMBER :: 20799-24-0

LAST UPDATED :: 199506

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C22-H29-N-O3

MOLECULAR WEIGHT :: 355.52

WISWESSER LINE NOTATION :: L E5 B666 OY MUTJ E1 FOV1 F1UU1 OUNQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 1-5 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 10(3),67,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4 mg/kg

SEX/DURATION :: female 6-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)

REFERENCE :: SCYYDZ Shengzhi Yu Biyun. Reproduction and Contraception. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) 1980- Volume(issue)/page/year: 10(3),67,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1500 ug/kg

SEX/DURATION :: female 2-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(6),53,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 5 mg/kg

SEX/DURATION :: female 2 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(6),53,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 mg/kg

SEX/DURATION :: female 2-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(6),53,1981

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 mg/kg

SEX/DURATION :: female 2-4 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

REFERENCE :: YHTPAD Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. Volume(issue)/page/year: 16(6),53,1981

Related Compounds

10-fluoroethindrone
17 alpha-cyanomethyl-19-nortestosterone
17-alpha-Ethynyl-estr-5(10)-ene-3-beta,17-beta-diol
3-Oxidido 17-alpha-ethynyl 17-beta-hydroxy estra-4,9,11-triene [French ]
4-ESTREN-17-ALPHA-ETHYNYL-6-BETA, 17-BETA-DIOL-3-ONE
Levonorgestrel
5-Bromo-2-chloro-4-ethyl-3-nitropyridine
5-Bromo-3-(cyclopropylmethoxy)-2-methylpyridine
tert-Butyl 1-((4-methoxybenzyl)amino)-8-azaspiro[4.5]decane-8-carboxylate
2-(7-Azaspiro[3.5]nonan-1-yl)isoindoline-1,3-dione
Benzyl 3-methyl-1-oxo-8-azaspiro[4.5]decane-8-carboxylate
Tert-butyl 3-methyl-4-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate
1-[[(1,1-Dimethylethyl)sulfinyl]amino]-3-methyl-8-azaspiro[4.5]decane-8-carboxylic acid 1,1-dimethylethyl ester
6-Bromo-3-[[3-chloro-2-(dimethylamino)-4-pyridinyl]thio]-2-pyrazinamine
3-[(3-Amino-5-chloro-2-pyrazinyl)thio]-2-chlorobenzamide
2-(5-Bromopyridin-3-yl)-1lambda6,2-thiazolidine-1,1-dione

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