L-tert-Leucine

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Names

[ CAS No. ]:
20859-02-3

[ Name ]:
L-tert-Leucine

[Synonym ]:
MFCD00002617
L-Tert-Leucine
3-Methyl-L-valine
L-Valine, 3-methyl-
L-tert-leucin
L-2-tert-Butylglycine
Valine, 3-methyl-
(S)-2-Amino-3,3-dimethylbutyric acid
LEUCINE,L
(S)-2-Amino-3,3-dimethylbutanoic acid
3-Methyl valine
EINECS 200-522-0
3-Methylvaline
(S)-2-Amino-4-methylpentanoic acid
L-α-tert-Butylglycine
T-BUTYL GLYCINE
L-tert
H-L-LEU-OH
QVYZX1&1&1 &&L or S Form
L-2-amino-3,3-dimethylbutanoic acid
(2S)-2-amino-3,3-dimethylbutanoic acid
L-Tert-Leu-OH

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
217.7±23.0 °C at 760 mmHg

[ Melting Point ]:
300 °C

[ Molecular Formula ]:
C6H13NO2

[ Molecular Weight ]:
131.173

[ Flash Point ]:
85.5±22.6 °C

[ Exact Mass ]:
131.094635

[ PSA ]:
63.32000

[ LogP ]:
0.55

[ Vapour Pressure ]:
0.1±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.464

[ Water Solubility ]:
125.5 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
OH2850000

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Boc-Tle-OH
  • (S)-2-Azido-3,3-dimethylbutanoicacid
  • Butanamide, 2-amino-3,3-dimethyl-, (2S)-
  • (2S)-2-benzamido-3,3-dimethylbutanoic acid
  • L-tert-leucine hydrochloride
  • 1,1,1-trichloro-3,3-dimethylbutan-2-one
  • (R)-1,1,1-trichloromethyl-3,3-dimethyl-2-butanol
  • (R)-2-amino-3,3-dimethyl-butyric acid amide

DownStream

  • sodium,(2S)-2-[(2-diphenylphosphanylphenyl)methylideneamino]-3,3-dimethylbutanoate
  • Boceprevir
  • (S)-2-CHLORO-1-(3,4-DICHLOROPHENYL)ETHANOL
  • (S)-(-)-2,2-BIS(DI-P-TOLYLPHOSPHINO)-1,1-BINAPHTHYL
  • Pivaldehyde
  • (S)-2-amino-N,3,3-trimethylbutanamide
  • (S)-3-PHENYL-1-(PHENYLMETHYL)[3,4-BIPIPERIDINE]-2,6-DIONEMONOHYDROCHLORIDE
  • (S)-(-)-4-tert-Butyloxazolidine-2,5-dione
  • Cbz-L-tert-leucine
  • Boc-Tle-OH

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Highly selective asymmetric acetate aldol reactions of an N-acetyl thiazolidinethione reagent.

Org. Lett. 6 , 23-25, (2004)

[reaction: see text] A highly diastereoselective acetate aldol reaction that uses a tert-leucine-derived thiazolidinethione auxiliary and dichlorophenylborane has been developed. The reaction proceeds...

Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acids.

Nature 461(7266) , 968-70, (2009)

Alpha-amino acids are the building blocks of proteins and are widely used as components of medicinally active molecules and chiral catalysts. Efficient chemo-enzymatic methods for the synthesis of ena...

An efficient and selective enzymatic oxidation system for the synthesis of enantiomerically pure D-tert-leucine.

Org. Lett. 5(20) , 3649-50, (2003)

[reaction: see text] d-tert-Leucine was prepared with an enantiomeric excess of >99% by an enzyme-catalyzed oxidative resolution of the racemic mixture of dl-tert-leucine with use of leucine dehydroge...


More Articles

Related Compounds

  • L-Tert-Leucine
  • Z-L-TERT-LEUCINE
  • Z-L-TERT-LEUCINE
  • BOC-L-TERT-LEUCINE
  • Boc-L-tert-leucine
  • Fmoc-L-tert-leucine
  • N-[1-(3-Cyanopyrazin-2-yl)azetidin-3-yl]-6-ethoxy-N-methylpyridine-3-carboxamide
  • 3-{3-[Methyl({[3-(trifluoromethyl)phenyl]methyl})amino]azetidin-1-yl}pyrazine-2-carbonitrile
  • 4-(5-Bromofuran-2-carbonyl)-1-(2-methoxypyridin-4-yl)piperazin-2-one
  • 4-(5-Bromopyridine-3-carbonyl)-1-[2-(trifluoromethyl)pyridin-4-yl]piperazin-2-one
  • N-[4-({3-[(pyrimidin-2-yloxy)methyl]piperidin-1-yl}methyl)phenyl]acetamide
  • N-[1-(3-Cyanopyrazin-2-yl)azetidin-3-yl]-2-(2,4-difluorophenyl)-N-methylacetamide
  • 4-(4-Bromothiophene-2-carbonyl)-1-(2-methoxypyridin-4-yl)piperazin-2-one
  • N-[4-({3-[(pyridin-3-yloxy)methyl]azetidin-1-yl}methyl)phenyl]acetamide
  • 5-Methyl-2-[(1-{[2-(trifluoromethyl)phenyl]methyl}piperidin-4-yl)oxy]pyrimidine
  • 5-Methyl-2-[(1-{[4-(trifluoromethyl)phenyl]methyl}piperidin-4-yl)oxy]pyrimidine