(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

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Names

[ CAS No. ]:
209414-27-7

[ Name ]:
(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

[Synonym ]:
(2S)-2-(2-Amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol
Benzenemethanol, 2-amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)-, (αS)-
(2S)-2-(2-Amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
Efavirenz Related CoMpound A

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
425.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H11ClF3NO

[ Molecular Weight ]:
289.681

[ Flash Point ]:
210.9±28.7 °C

[ Exact Mass ]:
289.048126

[ PSA ]:
46.25000

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.575

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethynylcyclopropane
  • 1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone
  • magnesium,ethynylcyclopropane,chloride
  • 5-Chloro-1-pentyne
  • (S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
  • lithium,ethynylcyclopropane
  • 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-ol
  • 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one
  • 5-Chloro-2-nitrobenzaldehyde

DownStream

  • Efavirenz
  • ENT Efavirenz
  • [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • (S)-5-Bromo-2-(2-hydroxypropan-2-YL)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide
  • Azomethine HR
  • 2-Methyl-2-(pyrimidin-4-yl)propanenitrile
  • 6'-Bromo-3'-fluoro-2'-hydroxyphenacyl bromide
  • 4-Benzyl-8-(6-methylpyrimidin-4-yl)-1,4,8-oxadiazecane
  • 1-Benzyl-n-(2-ethylphenyl)-2-oxo-1,6-diazaspiro[3.3]heptane-6-carboxamide
  • 3-(8-Benzyl-1,4,8-oxadiazecan-4-yl)-N-methoxy-N-methylpropanamide
  • N-(Cyanomethyl)-2-[3-methoxy-3-(trifluoromethyl)azetidin-1-yl]acetamide
  • 4-[2-Cyano-2-(cyclopentylcarbamoyl)eth-1-en-1-yl]-2-hydroxybenzoic acid
  • 4-[2-(Butylcarbamoyl)-2-cyanoeth-1-en-1-yl]-2-hydroxybenzoic acid
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