(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

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Names

[ CAS No. ]:
209414-27-7

[ Name ]:
(S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol

[Synonym ]:
(2S)-2-(2-Amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluoro-3-butyn-2-ol
Benzenemethanol, 2-amino-5-chloro-α-(2-cyclopropylethynyl)-α-(trifluoromethyl)-, (αS)-
(2S)-2-(2-Amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
Efavirenz Related CoMpound A

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
425.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C13H11ClF3NO

[ Molecular Weight ]:
289.681

[ Flash Point ]:
210.9±28.7 °C

[ Exact Mass ]:
289.048126

[ PSA ]:
46.25000

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.575

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2922199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethynylcyclopropane
  • 1-(2-Amino-5-chlorophenyl)-2,2,2-trifluoroethanone
  • magnesium,ethynylcyclopropane,chloride
  • 5-Chloro-1-pentyne
  • (S)-2-(5-chloro-2-nitrophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol
  • lithium,ethynylcyclopropane
  • 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-ol
  • 1-(5-chloro-2-nitrophenyl)-3-cyclopropylprop-2-yn-1-one
  • 5-Chloro-2-nitrobenzaldehyde

DownStream

  • Efavirenz
  • ENT Efavirenz
  • [4-Chloro-2-[(1S)-3-cyclopropyl-1-hydroxy-1-(trifluoromethyl)-2-propynyl)phenyl]carbamic Acid Methyl Ester

Customs

[ HS Code ]: 2922199090

[ Summary ]:
2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • (2-Bromo-cyclopent-2-enyl)-acetaldehyde
  • N-[(4-Fluorophenyl)methyl]-4-methanesulfonyl-2-(1-oxo-2,3-dihydro-1H-isoindol-2-YL)butanamide
  • 5-(2,2-Dimethylpropyl)-1,2-dihydro-3h-pyrazol-3-one
  • (S)-2-(tert-Butoxy)propanoic acid
  • 1-(4-Benzhydrylpiperazin-1-yl)-2-(3-piperidin-1-ylquinoxalin-2-yl)sulfanylethanone
  • 2-Bromo-1-(4-methyl-3-nitrophenyl)ethan-1-ol
  • 2,4,6-Trichloro-3-nitroquinoline
  • 3-((3,4-dichlorophenyl)sulfonyl)-8-methoxy-2H-chromen-2-one
  • 6,8-di-tert-butyl-3-(4-methoxybenzenesulfonyl)-2H-chromen-2-one
  • 7-benzoyl-5-benzyl-2H,5H,8H-[1,3]dioxolo[4,5-g]quinolin-8-one
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