10H-Phenothiazin-3-ol,8-chloro-10-[3-(dimethylamino)propyl]-

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Names

[ CAS No. ]:
2095-62-7

[ Name ]:
10H-Phenothiazin-3-ol,8-chloro-10-[3-(dimethylamino)propyl]-

[Synonym ]:
7-OCPZ
7-OHCPZ
7-Hydroxychlorpromazine
7-hydroxychlorpropazine

Chemical & Physical Properties

[ Density]:
1.281g/cm3

[ Boiling Point ]:
513.6ºC at 760 mmHg

[ Molecular Formula ]:
C17H19ClN2OS

[ Molecular Weight ]:
334.86400

[ Flash Point ]:
264.4ºC

[ Exact Mass ]:
334.09100

[ PSA ]:
52.01000

[ LogP ]:
4.66500

[ Vapour Pressure ]:
3.59E-11mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO0175000
CHEMICAL NAME :
Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-7-hydroxy-
CAS REGISTRY NUMBER :
2095-62-7
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C17-H19-Cl-N2-O-S
MOLECULAR WEIGHT :
334.89
WISWESSER LINE NOTATION :
T C666 BN ISJ B3N1&1 EG LQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
119 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 62,715,1973
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974- Volume(issue)/page/year: 4,2425,1965

Safety Information

[ HS Code ]:
2934300000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Chlorpromazine
  • Phenothiazin-3-ol, 8-chloro-
  • 10H-Phenothiazine,2-chloro-7-(1-methylethoxy)-
  • 2-Chloro-7-(MethoxyMethoxy)-10H-phenothiazine
  • 3-Chloro-N,N-dimethylpropan-1-amine

DownStream

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 1-(5-Amino-2-ethyl-phenyl)hexahydropyrimidine-2,4-dione
  • 1-[5-Amino-2-(difluoromethoxy)phenyl]hexahydropyrimidine-2,4-dione
  • 1-(5-Amino-2-methyl-phenyl)hexahydropyrimidine-2,4-dione
  • 5-[({5-azaspiro[3.4]octan-8-yl}methyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 2-(2,6-dioxopiperidin-3-yl)-5-({[4-(ethylamino)phenyl]methyl}amino)-2,3-dihydro-1H-isoindole-1,3-dione
  • 5-({2-azabicyclo[4.2.0]octan-5-yl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 2-(2,6-dioxopiperidin-3-yl)-5-({[(1r,4r)-4-(aminomethyl)-4-fluorocyclohexyl]methyl}amino)-2,3-dihydro-1H-isoindole-1,3-dione
  • rac-5-({[(2R,4aR,7aR)-octahydrocyclopenta[b][1,4]oxazin-2-yl]methyl}amino)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 2-(1-phenyl-1H-1,3-benzodiazol-2-yl)ethan-1-amine dihydrochloride
  • 5-(6,6-difluoro-1,4-diazepan-1-yl)-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
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