Entinostat (MS-275)

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Names

[ CAS No. ]:
209783-80-2

[ Name ]:
Entinostat (MS-275)

[Synonym ]:
Entinostat (MS-275)
MS-275
SNDX-275
Entinostat
pyridin-3-ylmethyl 4-((2-aminophenyl)carbamoyl)benzylcarbamate
Entinostat (MS-275,SNDX-275)
3-Pyridinylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate
Pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate
Carbamic acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3-pyridinylmethyl ester
N-(2-Aminophenyl)-4-[N-(pyridine-3-ylmethoxycarbonyl)aminomethyl]benzamide
MS 275-27
((4-(((2-Aminophenyl)amino)carbonyl)phenyl)methyl)carbamic Acid 3-Pyridinylmethyl Ester

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
566.7±50.0 °C at 760 mmHg

[ Melting Point ]:
159-160ºC

[ Molecular Formula ]:
C₂₁H₂₀N₄O₃

[ Molecular Weight ]:
376.409

[ Flash Point ]:
296.6±30.1 °C

[ Exact Mass ]:
376.153534

[ PSA ]:
106.34000

[ LogP ]:
1.46

[ Appearance of Characters ]:
solid

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.672

[ Storage condition ]:
−20°C

[ Water Solubility ]:
DMSO: 38 mg/mL, soluble

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335-H360

[ Precautionary Statements ]:
P201-P261-P301 + P310-P305 + P351 + P338-P308 + P313

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
UN 2811 6.1 / PGIII

[ WGK Germany ]:
3

[ HS Code ]:
29333990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

o-Phenylenediamine
4-({[(3-Pyridinylmethoxy)Carbonyl]Amino}Methyl)Benzoic Acid
1,3-Dimethyl-2-imidazolidinone
Nicotinyl alcohol
pyrid-3-ylmethyl carbonylimidazolide
1-{4-[N-(pyridin-3-ylmethoxycarbonyl)-aminomethyl]benzoyl}imidazole

DownStream

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Arch. Toxicol. 89 , 1599-618, (2015)

Test systems to identify developmental toxicants are urgently needed. A combination of human stem cell technology and transcriptome analysis was to provide a proof of concept that toxicants with a rel...