Tafluprost acid

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Names

[ CAS No. ]:
209860-88-8

[ Name ]:
Tafluprost acid

[Synonym ]:
(5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl}-5-heptenoic acid
5-Heptenoic acid, 7-[(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-, (5Z)-
tafluprost acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
575.9±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₈F₂O₅

[ Molecular Weight ]:
410.452

[ Flash Point ]:
302.1±30.1 °C

[ Exact Mass ]:
410.190491

[ PSA ]:
86.99000

[ LogP ]:
2.80

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.579

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(4-Carboxybutyl)triphenylphosphonium bromide
Dimethyl 2-oxo-3-phenoxypropylphosphonate
(-)-Corey aldehyde benzoate
(3aR,4R,5R,6aS)-2-oxo-4-((E)-3-oxo-4-phenoxybut-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate
(3AR,4R,5R,6AS)-4-((E)-3,3-DIFLUORO-4-PHENOXYBUT-1-EN-1-YL)-2-OXOHEXAHYDRO-2H-CYCLOPENTA[B]FURAN-5-YL BENZOATE
(3AR,4R,5R,6AS)-4-((E)-3,3-DIFLUORO-4-PHENOXYBUT-1-EN-1-YL)-5-HYDROXYHEXAHYDRO-2H-CYCLOPENTA[B]FURAN-2-ONE