LY-411575

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Names

[ CAS No. ]:
209984-57-6

[ Name ]:
LY-411575

[Synonym ]:
N2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamide
Benzeneacetamide, N-[(1S)-2-[[(7S)-6,7-dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-α-hydroxy-, (αS)-
N-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyacetyl]-N-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide
cc-581
LY411575

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
836.0±65.0 °C at 760 mmHg

[ Melting Point ]:
328.47°C

[ Molecular Formula ]:
C26H23F2N3O4

[ Molecular Weight ]:
479.475

[ Flash Point ]:
459.4±34.3 °C

[ Exact Mass ]:
479.165649

[ PSA ]:
98.74000

[ LogP ]:
4.75

[ Appearance of Characters ]:
white to beige

[ Vapour Pressure ]:
0.0±3.2 mmHg at 25°C

[ Index of Refraction ]:
1.652

[ Storage condition ]:
?20°C

[ Water Solubility ]:
DMSO: soluble5mg/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
29337900

Articles

Targeting both Notch and ErbB-2 signalling pathways is required for prevention of ErbB-2-positive breast tumour recurrence.

Br. J. Cancer 105 , 796-806, (2011)

We reported that Notch-1, a potent breast oncogene, is activated in response to trastuzumab and contributes to trastuzumab resistance in vitro. We sought to determine the preclinical benefit of combin...


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Related Compounds

  • LY-411575 (isomer 1)
  • Deshydroxy LY-411575
  • LY 368962
  • LY 295427
  • ly 272015 hydrochloride
  • LY 344864 S-enantiomer
  • 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanamido]-5,5-dimethylhexanoic acid
  • 2-{[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]methyl}-3,3,3-trifluoropropanoic acid
  • 3-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]-2-(trifluoromethyl)propanoic acid
  • 1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]-3-methylazetidine-3-carboxylic acid
  • 1-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-3-methylazetidine-3-carboxylic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)propanoyl]-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
  • 2-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanoyl]-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
  • 2-{1-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]cyclopropanecarbonyl}-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
  • 2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylbutanoyl]-2-azabicyclo[2.1.1]hexane-5-carboxylic acid
  • 3-cyclobutyl-3-[(2R)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]propanoic acid