4-(4-nitro-phenyl)-thiazol-2-ylamine

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Names

[ CAS No. ]:
2104-09-8

[ Name ]:
4-(4-nitro-phenyl)-thiazol-2-ylamine

[Synonym ]:
2-Thiazolamine,4-(4-nitrophenyl)
4-(4-NITRO-PHENYL)-THIAZOL-2-YLAMINE
2-Amino-4-(4-nitrophenyl)thiazole
4-(4-NITROPHENYL)THIAZOL-2-AMINE
2-Amino-4-(p-nitrophenyl)thiazole
4-(4-NITROPHENYL)-1,3-THIAZOLE-2-YLAMINE
4-(4-Nitrophenyl)-2-thiazolamine
2-AMINO-4-(4-NITROPHENYL)-1,3-THIAZOLE
THIAZOLE,2-AMINO-4-(p-NITROPHENYL)
2-amino-4-(4'-nitrophenyl)-1,3-thiazole
2-THIAZOLAMINE,4-(4-NITROPHENYL)-
4-(4-NITROPHENYL)-2-THIAZOLYLAMINE
4-(4-NITROPHENYL)THIAZOL-2-YLAMINE
MFCD00170222

Chemical & Physical Properties

[ Density]:
1.459g/cm3

[ Boiling Point ]:
448.4ºC at 760 mmHg

[ Melting Point ]:
283-287ºC

[ Molecular Formula ]:
C9H7N3O2S

[ Molecular Weight ]:
221.23600

[ Flash Point ]:
225ºC

[ Exact Mass ]:
221.02600

[ PSA ]:
112.97000

[ LogP ]:
3.40490

[ Vapour Pressure ]:
3.11E-08mmHg at 25°C

[ Index of Refraction ]:
1.692

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ2860000
CHEMICAL NAME :
Thiazole, 2-amino-4-(p-nitrophenyl)-
CAS REGISTRY NUMBER :
2104-09-8
BEILSTEIN REFERENCE NO. :
0200321
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H7-N3-O2-S
MOLECULAR WEIGHT :
221.25
WISWESSER LINE NOTATION :
T5N CSJ BZ ER DNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2150 mg/kg/13W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Skin and Appendages - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 54,841,1975
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9600 mg/kg/46W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Blood - leukemia
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 33,1593,1973

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XJ2860000

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • p-nitrophenacyl bromide
  • 4-Nitroacetophenone
  • imino-[2-(4-nitrophenyl)-2-oxo-ethylidene]azanium
  • Ethanone,2-chloro-1-(4-nitrophenyl)-
  • Ethanol

DownStream

  • 4-(4-AMINO-PHENYL)-THIAZOL-2-YLAMINE
  • n-(4-(4-amino-3,5-thiazolyl)phenyl)ethanamide
  • 2-(ethylamino)-N-[4-(4-nitrophenyl)-1,3-thiazol-2-yl]acetamide
  • 2-azido-4-(4-nitrophenyl)-1,3-thiazole

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Mass spectrometry of 2-substituted-4-arylthiazoles. II--Identification of microsomal nitroreduction product by mass spectrometry.

Biomed. Mass Spectrom. 9(9) , 376-80, (1982)

Electron impact fragmentation of 2-methyl-4-(4-nitrophenyl)-thiazole and 2-amino-4-(4-nitrophenyl)-thiazoles were studied. Prominent fragment ions result from: (1) elimination of an NO2 radical and of...


More Articles

Related Compounds

  • [4-(4-nitro-phenyl)-thiazol-2-yl]-methanol
  • 4-(4-BROMO-3-NITROPHENYL)THIAZOL-2-YLAMINE
  • ALLYL-[4-(4-NITRO-PHENYL)-THIAZOL-2-YL]-AMINE
  • acetic acid-{N'-[4-(4-nitro-phenyl)-thiazol-2-yl]-hydrazide}
  • 2-tert-Butylamino-N-[4-(4-nitro-phenyl)-thiazol-2-yl]-acetamide
  • 4-(4-DIETHYLAMINO-PHENYL)-THIAZOL-2-YLAMINE
  • (2S,3R)-2-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]-3-methoxybutanoic acid
  • 2-(2-{[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)ethyl]sulfanyl}acetyl)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid
  • 1-{2-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-2-methylbutanamido}cyclobutane-1-carboxylic acid
  • 2-{1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoro-2-methylpropanamido]cyclobutyl}acetic acid
  • 3-cyclopropyl-3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methoxypropanamido]propanoic acid
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-{[4-hydroxy-3-(methylsulfanyl)butan-2-yl]carbamoyl}propanoic acid
  • 3-[4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanamido]-2-methoxypropanoic acid
  • 2-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)butanamido]cyclopentane-1-carboxylic acid
  • 2-{[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanamido]methyl}cyclohexane-1-carboxylic acid
  • 2-ethyl-3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pentanoyl]-1,3-thiazolidine-4-carboxylic acid
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