3,3',4,4'-TETRACHLOROAZOXYBENZENE

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Names

[ CAS No. ]:
21232-47-3

[ Name ]:
3,3',4,4'-TETRACHLOROAZOXYBENZENE

[Synonym ]:
Diazene,bis(3,4-dichlorophenyl)-,1-oxide
3,3',4,4'-tetrachloroazoxybenzole
TCAOB
bis-(3,4-dichloro-phenyl)-diazene-N-oxide
Azoxybenzene,3,3',4,4'-tetrachloro
3,3',4,4'-Tetrachlor-azoxybenzol
3,3',4,4'-TETRACHLOROAZOXYBENZENE
Bis-(3,4-dichlor-phenyl)-diazen-N-oxid
Bis(3,4-dichlorophenyl)diazene 1-oxide
3,4,3',4'-Tetrachloroazoxybenzene
3,4,3',4'-Tetrachlor-azoxybenzol

Chemical & Physical Properties

[ Density]:
1.53g/cm3

[ Boiling Point ]:
472.7ºC at 760 mmHg

[ Molecular Formula ]:
C12H6Cl4N2O

[ Molecular Weight ]:
336.00100

[ Flash Point ]:
239.7ºC

[ Exact Mass ]:
333.92300

[ PSA ]:
41.11000

[ LogP ]:
6.74910

[ Vapour Pressure ]:
1.19E-08mmHg at 25°C

[ Index of Refraction ]:
1.641

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CO4150000
CHEMICAL NAME :
Azoxybenzene, 3,3',4,4'-tetrachloro-
CAS REGISTRY NUMBER :
21232-47-3
LAST UPDATED :
199712
DATA ITEMS CITED :
11
MOLECULAR FORMULA :
C12-H6-Cl4-N2-O
MOLECULAR WEIGHT :
336.00

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
80 mg/kg/17W-C
TOXIC EFFECTS :
Liver - changes in liver weight Blood - changes in erythrocyte (RBC) count Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
650 mg/kg/13W-I
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
350 mg/kg/48D-I
TOXIC EFFECTS :
Liver - other changes Endocrine - changes in thymus weight Related to Chronic Data - changes in testicular weight
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg/28D-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
75600 ug/kg
SEX/DURATION :
female 14 day(s) pre-mating - 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - blood and lymphatic systems (including spleen and marrow) Reproductive - Effects on Newborn - live birth index (measured after birth)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
7560 ug/kg
SEX/DURATION :
female 14 day(s) pre-mating - 28 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
16 mg/kg
SEX/DURATION :
female 12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
6 mg/kg
SEX/DURATION :
female 11 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) Reproductive - Specific Developmental Abnormalities - urogenital system

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
134 mg/kg/4W (Continuous)
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,677,1985

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3,4-dichloro-N-hydroxyaniline
  • 1,2-Dichloro-4-nitrobenzene
  • 1-chloro-4-nitrosobenzene
  • N-(3,4-dichlorophenyl)-O-pivaloylhydroxylamine
  • 1,2-dichloro-4-nitrosobenzene
  • 3,3',4,4'-Tetrachloroazobenzene
  • 3,4-Dichloroaniline
  • 4-chlorophenylhydroxylamine
  • Benzyl alcohol
  • benzene

DownStream

Related Compounds

  • 3,3',4,4'-Tetrahydro-3,3'-bis(2,4a,5,6,7,8-hexahydronaphthalen-1-yl)-2,2'-bifuran-5,5'(2H,2'H)-dione
  • 3,3',4,4',5,5'-hexamethyl-2,2'-dipyrryl ketone
  • 3,3',4,4'-tetrakis(n-hexyloxy)biphenyl
  • 3,3'-[4,4'-(propane-2,2-diyl)bis(4,1-phenylene)]bis(oxy)diphthalonitrile
  • 3,3',4,4'-tetrahydroxy-2,2',5,5'-tetramethylbiphenyl
  • 3,3',4,4'-Tetrachlorobiphenyl
  • benzyl 3-methyl-4-oxo-2,3-dihydroquinoline-1-carboxylate
  • benzyl N-(5-oxo-10H-phenothiazin-5-ylidene)carbamate
  • 2-(oxan-3-yl)-1-(1H-pyrazol-4-yl)ethan-1-ol
  • 2-[2-[benzyloxycarbonyl(tetrahydrofuran-2-ylmethyl)amino]thiazol-4-yl]acetic acid
  • benzyl 6-(5-cyano-2-thienyl)-2,3-dihydro-1,4-benzoxazine-4-carboxylate
  • O2-benzyl O5-tert-butyl 4-(hydroxymethyl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrole-2,5-dicarboxylate
  • benzyl N-(5-bromo-4,6-dichloro-pyrimidin-2-yl)carbamate
  • 4-fluoro-3-iodo-5-[(2,2,2-trifluoroacetyl)amino]benzoic acid
  • benzyl N-[2-(2,2-dibromocyclopropyl)ethyl]carbamate
  • methyl 2-(tert-butoxycarbonylamino)-3-iodo-benzoate
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