3-(dimethylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride

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Names

[ CAS No. ]:
2125-49-7

[ Name ]:
3-(dimethylamino)-1-(4-methoxyphenyl)propan-1-one hydrochloride

[Synonym ]:
3-dimethylamino-1-(4-methoxyphenyl)-1-propanone hydrochloride
3-(DIMETHYLAMINO)-4'-METHOXYPROPIOPHENONE HYDROCHLORIDE
beta-(Dimethylamino)-4'-methoxypropiophenone hydrochloride

Chemical & Physical Properties

[ Density]:
1.027g/cm3

[ Boiling Point ]:
318.2ºC at 760 mmHg

[ Melting Point ]:
184-186 ºC (ethanol acetone )

[ Molecular Formula ]:
C12H18ClNO2

[ Molecular Weight ]:
243.73000

[ Flash Point ]:
146.2ºC

[ Exact Mass ]:
243.10300

[ PSA ]:
29.54000

[ LogP ]:
2.63160

[ Vapour Pressure ]:
0.000368mmHg at 25°C

[ Index of Refraction ]:
1.512

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UH0730000
CHEMICAL NAME :
Propiophenone, 3-(dimethylamino)-4'-methoxy-, hydrochloride
CAS REGISTRY NUMBER :
2125-49-7
LAST UPDATED :
199203
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C12-H17-N-O2.Cl-H
MOLECULAR WEIGHT :
243.76

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 25,437,1962
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
275 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 12,994,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
258 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 24,833,1990

Safety Information

[ HS Code ]:
2923900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formaldehyde
  • Dimethylamine hydrochloride
  • Acetanisole
  • N,N-Dimethylmethyleneiminium chloride
  • Dimethylamine

DownStream

  • 1-(4-methoxyphenyl)-3-(1,2,4-triazol-1-yl)propan-1-one
  • 1-[2-(4-methoxybenzoyl)prop-2-enyl]pyridin-2-one
  • ethyl 6-(4-methoxyphenyl)-2-methylpyridine-3-carboxylate
  • 4'-Methoxypropiophenone
  • 3-(4-methoxyphenyl)cyclohex-2-en-1-one
  • 1-(4-methoxyphenyl)prop-2-en-1-one
  • [3-(dimethylamino)-1-(4-methoxyphenyl)propyl] phenyl carbonate,hydrochloride
  • 2H-1,3,2-Oxazaphosphorine,2-chloro-3,4-dihydro-6-(4-methoxyphenyl)-3-phenyl-, 2-oxide
  • 2-chloro-6-(4-methoxyphenyl)-3-(4-methylphenyl)-1-oxa-3-aza-2$l^C17H17ClNO3P-phosphacyclohex-5-ene 2-oxide
  • 2H-1,3,2-Oxazaphosphorine,2-chloro-3,4-dihydro-3,6-bis(4-methoxyphenyl)-, 2-oxide

Customs

[ HS Code ]: 2923900090

[ Summary ]:
2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%