Crotocin

Names

[ CAS No. ]:
21284-11-7

[ Name ]:
Crotocin

[Synonym ]:
4-Isocrotonyloxy-7,8-epoxyscirp-9-ene
Antibiotic T
Trichothec-9-en-4-ol,7,8:12,13-diepoxy-,(2Z)-2-butenoate,(4beta,7beta,8beta)

Chemical & Physical Properties

[ Molecular Formula ]:
C19H24O5

[ Molecular Weight ]:
332.39100

[ Exact Mass ]:
332.16200

[ PSA ]:
60.59000

[ LogP ]:
2.15430

[ Vapour Pressure ]:
0mmHg at 25°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YD0117000
CAS REGISTRY NUMBER :
21284-11-7
LAST UPDATED :
199410
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C19-H24-O5
MOLECULAR WEIGHT :
332.43

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
810 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
700 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 38,536,1978

Safety Information

[ RIDADR ]:
UN 3172

Related Compounds

  • Benzyl 4-(3-bromophenyl)-5,6-dihydropyridine-1(2H)-carboxylate
  • 3-Chloro-[1,2,4]triazolo[4,3-a]pyridine-7-carbonitrile
  • 4-(3-Methylene-2,3-dihydro-1H-inden-5-yl)-1H-pyrazolo[3,4-b]pyridine
  • 1H-Imidazole-2-methanamine, 1-(3-pyrrolidinylmethyl)-
  • 3-(2-Fluoro-4-methoxyphenyl)propan-1-amine
  • 4-(2-{[(furan-2-yl)methyl](prop-2-yn-1-yl)amino}acetamido)-N,N-dimethylbenzamide
  • 3-(3-Methyl-1-benzofuran-2-yl)propan-1-amine
  • 2-(3-(trifluoromethyl)-1H-pyrazol-4-yl)acetonitrile
  • 2-(1-ethyl-3-methyl-1H-pyrazol-4-yl)acetic acid
  • 2-Fluoro-5-methylpyridine-3-acetic acid
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