6H-Purine-6-thione,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-

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Names

[ CAS No. ]:
2133-81-5

[ Name ]:
6H-Purine-6-thione,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-

Chemical & Physical Properties

[ Density]:
2.02g/cm3

[ Boiling Point ]:
709.1ºC at 760 mmHg

[ Molecular Formula ]:
C10H13N5O3S

[ Molecular Weight ]:
283.30700

[ Flash Point ]:
382.6ºC

[ Exact Mass ]:
283.07400

[ PSA ]:
154.30000

[ LogP ]:
0.29300

[ Vapour Pressure ]:
4.22E-21mmHg at 25°C

[ Index of Refraction ]:
1.93

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0745000
CHEMICAL NAME :
9H-Purine-6(1H)-thione, 2-amino-9-(2-deoxy-alpha-D-erythro-pentofuranosyl)-
CAS REGISTRY NUMBER :
2133-81-5
LAST UPDATED :
199703
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H13-N5-O3-S
MOLECULAR WEIGHT :
283.34
WISWESSER LINE NOTATION :
T56 BN DN FYM INJ FUS HZ B- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1 gm/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
1500 mg/kg/33D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
3 gm/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)

MUTATION DATA

TYPE OF TEST :
Host-mediated assay
TEST SYSTEM :
Rodent - mouse Cells - not otherwise specified
DOSE/DURATION :
100 umol/kg
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,1103,1975

Related Compounds

  • (2R,4R)-4-Hydroxy-N,N-dimethylpyrrolidine-2-carboxamide;hydrochloride
  • 4-(3-Fluoro-2-hydroxypropyl)-1,4-thiazepan-1-one
  • 3-Chloro-2-fluoro-5-hydroxybenzoic acid
  • 5-Amino-1-(2-methoxy-2-methylpropyl)-1,2-dihydropyridin-2-one
  • 2,4-Dioxo-6-phenyl-3-((pyrimidin-2-ylamino)methylene)cyclohexanecarbonitrile
  • 2-(3,5-Dimethylpyridin-2-yl)-3-methylbutanoic acid
  • 3,3',3'',3'''-(Porphyrin-5,10,15,20-tetrayl)tetrakis(1-ethylpyridin-1-ium) chloride
  • 6-Cyano-N-(6-piperidin-1-ylpyridin-3-yl)pyridine-3-sulfonamide
  • N-(Cyanomethyl)-N,4-dimethyl-3-methylsulfonylbenzamide
  • {3-[(3-amino-5-methyl-1H-pyrazol-1-yl)methyl]oxetan-3-yl}methanol
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