Mepitiostane

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Names

[ Name ]:
Mepitiostane

[Synonym ]:
2,3-Epithio-1H-cyclopenta[a]phenanthrene,androstane deriv.
2a,3a-Epithio-17b-(1-methoxycyclopentyloxy)-5a-androstane
2a,3a-Epithio-17b-(cyclopentylmethoxy)-5a-androstane
2a,3a-Epithio-5a-androstan-17b-yl 1-methoxycyclopentyl ether

Chemical & Physical Properties

[ Density]:
1.13g/cm3

[ Boiling Point ]:
485.2ºC at 760mmHg

[ Molecular Formula ]:
C₂₅H₄₀O₂S

[ Molecular Weight ]:
404.64900

[ Flash Point ]:
247.2ºC

[ Exact Mass ]:
404.27500

[ PSA ]:
43.76000

[ LogP ]:
6.42490

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.568

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BV8044500

CHEMICAL NAME :: 5-alpha-Androstane, 2-alpha,3-alpha-epithio-17-beta-(1-methoxycyclopentyl oxy)-

CAS REGISTRY NUMBER :: 21362-69-6

LAST UPDATED :: 199209

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C25-H40-O2-S

MOLECULAR WEIGHT :: 404.71

WISWESSER LINE NOTATION :: T G5 D6 C663 RSTJ C1 G1 HO- AL5TJ AO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 400 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes Skin and Appendages - dermatitis, other (after systemic exposure) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 41,758,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >6130 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 875 mg/kg/35D-C

TOXIC EFFECTS :: Endocrine - other changes Blood - normocytic anemia Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,779,1978

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 910 mg/kg/26W-C

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 16,739,1978 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 8 mg/kg

SEX/DURATION :: male 10 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 24,551,1974

Related Compounds

1-[(4-Methylpyridin-2-yl)methyl]piperazine
1-[(2-Methylpyridin-4-yl)methyl]piperazine
2-(3-Amino-1-benzylpyrrolidin-3-yl)ethan-1-ol
2-Hexyl-2-methyl-1,3-dioxane-4,6-dione
(Z)-N-hydroxy-2-methylpropanecarbonimidoyl chloride
Tert-butyl 5-(cyanomethyl)-2-methyl-piperidine-1-carboxylate
5-Methoxy-1H-benzo[d][1,3]oxazin-2(4H)-one
(3S)-3-Amino-3-(4-methylpyridin-3-yl)propanamide
8-Methoxy-1H-benzo[d][1,3]oxazin-2(4H)-one
3-(piperidin-2-yl)-1H-indazole

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