Virginiamycin M1

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Names

[ Name ]:
Virginiamycin M1

[Synonym ]:
Vernamycin A
Staphylomycin M1
STAPHYLOMYCIN
Antibiotic PA-114A1
pristinamycin component IIA
VIRGINIAMYCINE
MIKAMYCIN A
Pristinamycin IIA
VIRGINIAMYCIN M1
Streptogramin A

Chemical & Physical Properties

[ Density]:
1.26 g/cm3

[ Boiling Point ]:
825.2ºC at 760 mmHg

[ Melting Point ]:
165-170 °C

[ Molecular Formula ]:
C₂₈H₃₅N₃O₇

[ Molecular Weight ]:
525.59300

[ Flash Point ]:
452.9ºC

[ Exact Mass ]:
525.24800

[ PSA ]:
139.04000

[ LogP ]:
2.92610

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.586

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

Purification and characterization of virginiamycin M1 reductase from Streptomyces virginiae.

Antimicrob. Agents Chemother. 42 , 2985-2988, (1998)

Virginiamycin M1 (VM1), produced by Streptomyces virginiae, is a polyunsaturated macrocyclic lactone antibiotic belonging to the virginiamycin A group. S. virginiae possesses an activity which stereos...

PapR6, a putative atypical response regulator, functions as a pathway-specific activator of pristinamycin II biosynthesis in Streptomyces pristinaespiralis.

J. Bacteriol. 197(3) , 441-50, (2015)

There are up to seven regulatory genes in the pristinamycin biosynthetic gene cluster of Streptomyces pristinaespiralis, which infers a complicated regulation mechanism for pristinamycin production. I...

VisG is eβential for biosynthesis of virginiamycin S, a streptogramin type B antibiotic, as a provider of the nonproteinogenic amino acid phenylglycine Fitria Ningsih, Shigeru Kitani, et al.

Microbiology 167 , 3213 - 3220, (2011)

13-deoxyvirginiamycin M1
13,14-anhydrovirginiamycin M1
15-Dihydro-13,14-anhydrovirginiamycin M1
Virginiamycin S1
virginiamycin butanolide C
virginiamycin butanolide D
Phenyl 4-((4-acetamido-2-methylphenylsulfonamido)methyl)piperidine-1-carboxylate
Phenyl 4-((4-ethoxy-3,5-dimethylphenylsulfonamido)methyl)piperidine-1-carboxylate
Phenyl 4-((2-bromophenylsulfonamido)methyl)piperidine-1-carboxylate
Phenyl 4-((5-bromothiophene-2-sulfonamido)methyl)piperidine-1-carboxylate
N-{[1-(4-methyl-1,2,3-thiadiazole-5-carbonyl)piperidin-4-yl]methyl}-1-phenylmethanesulfonamide
2-fluoro-N-((1-(4-methyl-1,2,3-thiadiazole-5-carbonyl)piperidin-4-yl)methyl)benzenesulfonamide
3,5-dimethyl-N-((1-(4-methyl-1,2,3-thiadiazole-5-carbonyl)piperidin-4-yl)methyl)isoxazole-4-sulfonamide
(E)-N-((1-(4-methyl-1,2,3-thiadiazole-5-carbonyl)piperidin-4-yl)methyl)-2-phenylethenesulfonamide
4-acetyl-N-((1-(4-methyl-1,2,3-thiadiazole-5-carbonyl)piperidin-4-yl)methyl)benzenesulfonamide
3-chloro-2-methyl-N-{[1-(4-methyl-1,2,3-thiadiazole-5-carbonyl)piperidin-4-yl]methyl}benzene-1-sulfonamide

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