o-Chloroacetophenone

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Names

[ CAS No. ]:
2142-68-9

[ Name ]:
o-Chloroacetophenone

[Synonym ]:
1-(2-Chlorophenyl)ethanone
Acetophenone,2'-chloro
2’-Chloroacetophenone
o-Chloroacetophonone
Ethanone, 1- (2-chlorophenyl)-
2′-Chloroacetophenone
o-Chloroacetophenone
acetophenone, 2'-chloro-
o-chlorophenyl methyl ketone
EINECS 218-397-6
2'-Chloroacetophenone
2‘-Chloroacetophenone
MFCD00000560
Ethanone, 1-(2-chlorophenyl)-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
195.5±13.0 °C at 760 mmHg

[ Melting Point ]:
52-56ºC

[ Molecular Formula ]:
C8H7ClO

[ Molecular Weight ]:
154.594

[ Flash Point ]:
89.6±11.0 °C

[ Exact Mass ]:
154.018539

[ PSA ]:
17.07000

[ LogP ]:
2.09

[ Vapour Pressure ]:
0.4±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.532

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM6310000
CHEMICAL NAME :
Acetophenone, 2'-chloro-
CAS REGISTRY NUMBER :
2142-68-9
BEILSTEIN REFERENCE NO. :
1858916
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C8-H7-Cl-O
MOLECULAR WEIGHT :
154.60
WISWESSER LINE NOTATION :
GR BV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
880 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CroHP# Personal Communication from H.P. Crocker, Ultimate Holding Co.-Reckitt & Colman Ltd., London, UK, Sept. 2, 1980 Volume(issue)/page/year: 02SEPT1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7952 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39-S45-S36/37/39-S28A

[ RIDADR ]:
UN 3416 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
AM6310000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2914509090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-Chloro-2-ethynylbenzene
  • 2-Chlorostyrene
  • 1-(2-Chlorophenyl)-1-ethanol
  • 2-Chlorophenylboronic aicd
  • Ethanoic anhydride
  • N-[1-(2-chlorophenyl)ethylidene]hydroxylamine
  • Acetyl chloride
  • Chlorobenzene
  • Acetophenone

DownStream

  • 3-chloro-3-(2-chlorophenyl)prop-2-enenitrile
  • 2-Bromo-1-(2-chlorophenyl)ethanone
  • 2,2-dibromo-1-(2-chlorophenyl)ethanone
  • 2'-Aminoacetophenone
  • 3-Methyl-1-benzothiophene-2-carboxylic acid
  • (2-Acetylphenyl)boronic acid
  • Methyl (2-chlorophenyl)acetate
  • 1-chloro-2-(2-iodo-1,1-dimethoxyethyl)benzene
  • 2-Acetylbenzonitrile
  • Xanthoxylin

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

[Saccharomyces cerevisiae B5 efficiently and stereoselectively reduces 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol in the presence of 5% ethanol].

Sheng Wu Gong Cheng Xue Bao 19(2) , 206-11, (2003)

(R)-chlorprenaline, a selective activator of beta2 receptor and an effective drug for bronchitis and asthma, is industrially prepared from (R)-2'-chloro-1-phenyl-ethanol. In this communication, we des...

Spectral differentiation and gas chromatographic/mass spectrometric analysis of the lacrimators 2-chloroacetophenone and o-chlorobenzylidene malononitrile.

J. Forensic Sci. 31(2) , 658-65, (1986)

2-Chloroacetophenone (CN) and o-chlorobenzylidene malononitrile (CS) are the most common chemical agents used as lacrimators in the United States. There is a lack of complete spectral data on these co...

Improving the enantioselective bioreduction of aromatic ketones mediated by Aspergillus terreus and Rhizopus oryzae: the role of glycerol as a co-solvent. Andrade LH, et al.

Tetrahedron Asymmetry 20(13) , 1521-25, (2009)


More Articles

Related Compounds

  • o-chloroacetophenone oxime
  • o-Nitrobenzyl-5 tetrahydro-5,6,7,7a 4H-thieno(3,2-c)pyridinone-2 oxala te [French]
  • o-(α-Methyl-β-chlor-vinyl)-cis-zimtsaeureamid
  • O-isopropyl-O'-(3'-azido-3'-deoxythymidin-5'-yl) phosphonate
  • O-ethyl-S-(2-(diisopropylamino)ethyl)(methyl)phosphonothiolate
  • O,O-diphenyl {[(benzyloxy)carbonyl]amino}(phenyl)methylphosphonate
  • 2-Chloro-5-ethyl-3-methylpyridine
  • 1,2,3-Tribromo-5-(tert-butyl)benzene
  • 2,4,4,4-Tetrachlorobutyl 2-chloro-2-propenoate
  • 4-(Dimethylamino)bicyclo[2.2.2]octane-1-carbaldehyde
  • 3-(5-methoxy-1H-indol-3-yl)butan-2-amine;hydrochloride
  • 4-Amino-3-(cyanomethoxy)-N-(1,1,3,3-tetramethylbutyl)benzamide
  • 2,3-Dihydro-5-phenyl-1H-pyrrolo[2,1-a]isoindole-6,9-dione
  • 1-(4-Bromo-2-ethoxyphenyl)ethylamine
  • Ethyl N-[6-(trifluoromethyl)-3-pyridinyl]carbamate
  • 2-(2-Bromobenzyl)-2,3-dimethylbutanoic acid
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