4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline

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Names

[ CAS No. ]:
214476-09-2

[ Name ]:
4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline

[Synonym ]:
ZLE0129
4-Chloro-7-ethoxy-6-nitro-3-quinolinecarbonitrile
4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile
4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Boiling Point ]:
485.3ºC at 760 mmHg

[ Molecular Formula ]:
C12H8ClN3O3

[ Molecular Weight ]:
277.66300

[ Flash Point ]:
247.3ºC

[ Exact Mass ]:
277.02500

[ PSA ]:
91.73000

[ LogP ]:
3.58998

[ Vapour Pressure ]:
1.43E-09mmHg at 25°C

[ Index of Refraction ]:
1.647

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Cyano-7-ethoxy-4-hydroxy-6-N-; acetylquinoline
  • Phosphorus pentachloride
  • 3-Cyano-7-ethoxy-4-hydroxy-6-nitroquinoline
  • 5-methoxy-2-methyl-4-nitroaniline
  • 3-ethoxy-4-nitroaniline
  • 2-ACETAMIDO-4-METHOXY-5-NITROTOLUENE
  • N-(5-ethoxy-2-methyl-4-nitrophenyl)acetamide
  • 2-acetylamino-4-ethoxy-5-nitrobenzoic acid
  • 3-Ethoxyaniline
  • 3-Quinolinecarbonitrile,7-ethoxy-4-hydroxy-(9CI)

DownStream

  • 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile
  • Neratinib (HKI-272)
  • Pelitinib
  • 6-amino-4-chloro-7-ethoxyquinoline-3-carbonitrile
  • HKI 357

Related Compounds

  • N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide
  • 4-Chloro-3-cyano-7-methoxy-6-quinolinyl acetate
  • 4-(3-Chloro-4-fluoroanilino)-3-cyano-7-ethyloxy-6-nitroquinoline
  • 4-Chloro-7-ethoxy-6-methoxy-3-quinolinecarbonitrile
  • 4-CHLORO-3-CYANO-6-FLUORO-2H-BENZOPYRAN
  • 4-[3-chloro-4-(2-pyridylmethoxy)anilino]-3-cyano-7-ethoxy-6-aminoquinoline hydrochloride
  • Methyl 4-(2-hydroxypropan-2-yl)oxane-4-carboxylate
  • (S)-2-Methylindolin-5-ol
  • (2S)-2-(4-Cyclobutylphenyl)propan-1-amine
  • 1-Ethyl-5-methoxy-1H-pyrazol-4-amine
  • (S)-2-(3-Fluoro-2-iodophenyl)pyrrolidine
  • (S)-1-(2-Bromo-5-fluorophenyl)propane-1,3-diol
  • (2s)-4-(4-Chloro-3-fluorophenyl)butan-2-amine
  • 7-(9H-Fluoren-9-ylmethoxycarbonyl)-3-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,5-a]pyrazine-1-carboxylic acid
  • 6-Amino-2-bromo-3-hydroxybenzoic acid
  • 4-Amino-3-bromo-5-hydroxybenzoic acid
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