4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline

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Names

[ CAS No. ]:
214476-09-2

[ Name ]:
4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline

[Synonym ]:
ZLE0129
4-Chloro-7-ethoxy-6-nitro-3-quinolinecarbonitrile
4-Chloro-7-ethoxy-6-nitro-quinoline-3-carbonitrile
4-Chloro-3-cyano-7-ethoxy-6-nitroquinoline

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Boiling Point ]:
485.3ºC at 760 mmHg

[ Molecular Formula ]:
C12H8ClN3O3

[ Molecular Weight ]:
277.66300

[ Flash Point ]:
247.3ºC

[ Exact Mass ]:
277.02500

[ PSA ]:
91.73000

[ LogP ]:
3.58998

[ Vapour Pressure ]:
1.43E-09mmHg at 25°C

[ Index of Refraction ]:
1.647

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Cyano-7-ethoxy-4-hydroxy-6-N-; acetylquinoline
  • Phosphorus pentachloride
  • 3-Cyano-7-ethoxy-4-hydroxy-6-nitroquinoline
  • 5-methoxy-2-methyl-4-nitroaniline
  • 3-ethoxy-4-nitroaniline
  • 2-ACETAMIDO-4-METHOXY-5-NITROTOLUENE
  • N-(5-ethoxy-2-methyl-4-nitrophenyl)acetamide
  • 2-acetylamino-4-ethoxy-5-nitrobenzoic acid
  • 3-Ethoxyaniline
  • 3-Quinolinecarbonitrile,7-ethoxy-4-hydroxy-(9CI)

DownStream

  • 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile
  • Neratinib (HKI-272)
  • Pelitinib
  • 6-amino-4-chloro-7-ethoxyquinoline-3-carbonitrile
  • HKI 357

Related Compounds

  • N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide
  • 4-Chloro-3-cyano-7-methoxy-6-quinolinyl acetate
  • 4-(3-Chloro-4-fluoroanilino)-3-cyano-7-ethyloxy-6-nitroquinoline
  • 4-Chloro-7-ethoxy-6-methoxy-3-quinolinecarbonitrile
  • 4-CHLORO-3-CYANO-6-FLUORO-2H-BENZOPYRAN
  • 4-[3-chloro-4-(2-pyridylmethoxy)anilino]-3-cyano-7-ethoxy-6-aminoquinoline hydrochloride
  • Methyl 3-(3,5-di-tert-butyl-4-methoxyphenyl)propanoate
  • 2-(1-Hydroxypropyl)-1,3-thiazole-5-carbaldehyde
  • (2S,4R)-1-[(benzyloxy)carbonyl]-4-methylpyrrolidine-2-carboxylic acid
  • N1-(3-methoxyphenyl)-2-methylpropane-1,2-diamine
  • 5-Fluoro-6-(4-morpholinyl)-2,1,3-benzoxadiazole
  • 2-Chloro-5-(3-(pyrrolidin-1-yl)propoxy)pyridine
  • 1-((4-Methyl-4H-1,2,4-triazol-3-yl)methyl)piperidin-4-amine
  • 1-(3-Methylphenyl)butane-2,3-dione
  • N,N-diethyl-4-(morpholin-2-yl)aniline
  • N,N-diethyl-4-(morpholin-3-yl)aniline
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