Methyl2,5-dihydroxybenzoate

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Names

[ CAS No. ]:
2150-46-1

[ Name ]:
Methyl2,5-dihydroxybenzoate

[Synonym ]:
2,5-dihydroxybenzoic acid methyl ester
2,5-dihydroxy-benzoic acid methyl ester
MFCD00016464
Benzoic acid, 2,5-dihydroxy-, methyl ester
Methyl2,5-dihydroxybenzoate
methyl 6-(trifluoromethylsulfonyloxy)coumarin-5-carboxylate
methyl 2,5-dihydroxy-benzoate
EINECS 218-427-8
Methyl 2,5-dihydroxybenzoate
Methyl Gentisate
Methyl-2,5-dihydroxybenzoate
Gentisic Acid Methyl Ester
Benzoic acid,2,5-dihydroxy-,methyl ester

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
328.2±22.0 °C at 760 mmHg

[ Melting Point ]:
86-88 °C(lit.)

[ Molecular Formula ]:
C8H8O4

[ Molecular Weight ]:
168.147

[ Flash Point ]:
137.6±15.8 °C

[ Exact Mass ]:
168.042252

[ PSA ]:
66.76000

[ LogP ]:
1.83

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.588

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2918199090

Synthetic Route

Precursor & DownStream

Precursor

  • Methanol
  • Gentisic acid
  • 2,4-Dihydroxybenzoic acid
  • methyl 2,5-diacetyloxybenzoate
  • methyl iodide
  • N-(benzyloxy)-5-((2-methoxyethoxy)methoxy)-2-phenoxybenzamide
  • 5-allyloxy-2-hydroxy-benzoic acid methyl ester
  • Sodium gentisate
  • Dimethyl sulfate

DownStream

  • methyl 2,5-bis(phenylmethoxy)benzoate
  • 2,5-dimethoxyphenyl isocyanate
  • 1-Hydroxy-2,3,4,7-tetramethoxyxanthone
  • 2,5-Dimethoxybenzoic acid
  • methyl 2,5-bis(trifluoromethylsulfonyloxy)benzoate
  • Methyl 2-hydroxy-5-methoxybenzoate
  • methyl 2,5-diacetyloxybenzoate
  • methyl 2,5-diphenylbenzoate
  • 2,5-Dihydroxy-N-(2-hydroxyethyl)benzamide
  • methyl 2,5-dimethoxybenzoate

Customs

[ HS Code ]: 2918290000

[ Summary ]:
HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles

Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors.

Biochem. Pharmacol. 57(6) , 663-72, (1999)

To discover safe and effective topical skin-lightening agents, we have evaluated alkyl esters of the natural product gentisic acid (GA), which is related to our lead compound methyl gentisate (MG), an...

Methyl 2, 5-dihydroxybenzoate. Brown CL, et al.

Acta Crystallogr. Sect. E Struct. Rep. Online 59(5) , 630-631, (2003)

Total Synthesis of (.+-.)-Euonyminol, the Sesquiterpenoid Nucleus of Cathedulin K-19, via an Epoxide Cascade Cyclization. White JD, et al.

J. Am. Chem. Soc. 117(38) , 9780-9781, (1995)


More Articles


Related Compounds

  • Methyl2,5-dihydroxybenzoate
  • METHYL2-(5-BROMO-2-METHYLTHIAZOL-4-YL)ACETATE
  • METHYL2-(5-CHLORO-2-METHYLTHIAZOL-4-YL)ACETATE
  • methyl2-(5,6,7,8-tetrahydro-4H-thieno[3,2-c]azepin-8-yl)acetate
  • 2,5-dihydroxybenzoate
  • Methyl 3,5-dioxocyclohexane-1-carboxylate
  • Methyl 2-(3-hydroxyphenyl)-2,4-dimethylpentanoate
  • 5-Methoxy-1-(phenylsulfonyl)-1h-pyrrolo[3,2-b]pyridin-2-ylboronic acid
  • 2-(4-Methylthiazole-2-carbonyl)benzoic acid
  • 2H-1-Benzopyran-3-carbonitrile, 5,6,7,8-tetrahydro-2,5-dioxo-
  • [3-(4-amino-1H-benzoimidazol-2-yl)-propyl]-methyl-carbamic acid tert-butyl ester
  • 2,2',2'',2'''-((15,35,55,75-Tetra-tert-butyl-2,4,6,8-tetrathia-1,3,5,7(1,3)-tetrabenzenacyclooctaphane-12,32,52,72-tetrayl)tetrakis(oxy))tetra(acetohydrazide)
  • Methyl 2-benzylisonicotinate
  • I(2)-D-Glucopyranoside, (3I(2),24Z)-stigmasta-5,24(28)-dien-3-yl, 6-(9Z,12Z)-9,12-octadecadienoate
  • 2-(2-(4-methoxyphenyl)acetyl)-N-methylbenzamide
  • 2-methyl-5-[(prop-2-en-1-yloxy)carbonyl]-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carboxylic acid
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