diftalone

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Names

[ CAS No. ]:
21626-89-1

[ Name ]:
diftalone

[Synonym ]:
L 5418
Aladione
Diftalona [INN-Spanish]
Phthalazino<2,3-b>phthalazin-5,12(7H,14H)-dion
Diftalonum [INN-Latin]
phthalazino<2,3-b>phthalazine-5,12-(14H,7H)dione
DIFTALONE
Phthalazino[2,3-b]phthalazine-5,12(7H,14H)-dione
7H,14H-phthalazino[2,3-b]phthalazine-5,12-dione
Phthalazino<2,3-b>phthalazin-5(14H),12(7H)-dion
EINECS 244-484-3
phthalazino<2,3-b>phthalazine-5,12-dione

Chemical & Physical Properties

[ Density]:
1.43g/cm3

[ Boiling Point ]:
462ºC at 760mmHg

[ Molecular Formula ]:
C16H12N2O2

[ Molecular Weight ]:
264.27900

[ Flash Point ]:
221.2ºC

[ Exact Mass ]:
264.09000

[ PSA ]:
40.62000

[ LogP ]:
2.08920

[ Vapour Pressure ]:
1.03E-08mmHg at 25°C

[ Index of Refraction ]:
1.733

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TH9250000
CHEMICAL NAME :
Phthalazino(2,3-b)phthalazine-5(14H),12(7H)-dione
CAS REGISTRY NUMBER :
21626-89-1
BEILSTEIN REFERENCE NO. :
0753163
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C16-H12-N2-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 70,479,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1970 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 70,479,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>7500 mg/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 22,352,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 22,352,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6350 mg/kg
TOXIC EFFECTS :
Biochemical - Metabolism (Intermediary) - effect on inflammation or mediation of inflammation
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,2003,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1600 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 70,479,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>7500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 22,352,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954- Volume(issue)/page/year: 22,352,1975

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 2-chloro-6-methyl-N-(piperidin-4-ylmethyl)pyrimidin-4-amine hydrochloride
  • 2-(Difluoromethyl)piperidin-4-one
  • 2-[(Cyclohex-2-en-1-yl)oxy]ethyl 3-oxobutanoate
  • 2-Chloro-4-methyl-6-(pyrrolidin-3-yloxy)pyrimidine hydrochloride
  • 2-(2-Bromo-5-fluorobenzylidene)-1,1-dimethylhydrazine
  • 2-Tert-butoxy-5-cyclopropoxy-3-iodopyridine
  • 2-(Cyclopropylmethyl)-5-(trifluoromethyl)phenol
  • 5-Cyclopropoxy-N,N,2-trimethylpyridin-3-amine
  • 4-Tert-butoxy-3-cyclopropoxy-5-isopropoxypyridine
  • 3-Cyclopropoxy-2-iodo-4-methylpyridine
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