Guanoxan

Names

[ CAS No. ]:
2165-19-7

[ Name ]:
Guanoxan

[Synonym ]:
2-Guanidinmethyl-2,3-dihydro-benzo<1,4>dioxin
Envacar
2-Guanidinomethyl-2,3-dihydro-benzo-<1,4>dioxin
Guanoxane
Guanoxon
Guanoxan
debrisoquin

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
389.9ºC at 760mmHg

[ Melting Point ]:
164-165°

[ Molecular Formula ]:
C10H13N3O2

[ Molecular Weight ]:
207.22900

[ Flash Point ]:
189.6ºC

[ Exact Mass ]:
207.10100

[ PSA ]:
80.36000

[ LogP ]:
1.50040

[ Vapour Pressure ]:
2.75E-06mmHg at 25°C

[ Index of Refraction ]:
1.639

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ME8510200
CHEMICAL NAME :
Guanidine, (1,4-benzodioxan-2-ylmethyl)-
CAS REGISTRY NUMBER :
2165-19-7
BEILSTEIN REFERENCE NO. :
1251616
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-N3-O2
MOLECULAR WEIGHT :
207.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
208 mg/kg/1Y
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,296,1969

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate
  • 2-azidomethyl-2,3-dihydro-1,4-benzodioxine
  • 2,3-Dihydro-1,4-benzodioxin-2-ylmethanol
  • DiBoc guanoxan
  • 1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine

DownStream

Related Compounds

  • Guanoxan-d4
  • DiBoc guanoxan
  • Guanoxan sulfate
  • (3R)-2,2-dimethylpentan-3-amine hydrochloride
  • 1-(trans-4-Heptylcyclohexyl)-4-methylbenzene
  • 1-Chloroethyl cyclopentanecarboxylate
  • [(2-Methoxy-3-pyridyl)methyl]azide
  • 2-[3-(3-oxo-3,4-dihydro-2H-1,4-benzoxazin-4-yl)propyl]-2,3-dihydro-1H-isoindole-1,3-dione
  • 5-Methyl-2-(pyridin-3-yl)-1,3-thiazole-4-carboxylic acid
  • 4-({[3-(Trifluoromethyl)phenyl]methyl}amino)cyclohexan-1-ol
  • 5-[(2,2,6,6-tetramethyl-4-piperidinyl)amino]-1,2,4-triazin-3(2H)-one
  • 4-(4-Phenylpiperidin-1-yl)aniline
  • Methyl 4-methanesulfonylaminomethyl-2-nitrobenzoate
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