Guanoxan

Names

[ CAS No. ]:
2165-19-7

[ Name ]:
Guanoxan

[Synonym ]:
2-Guanidinmethyl-2,3-dihydro-benzo<1,4>dioxin
Envacar
2-Guanidinomethyl-2,3-dihydro-benzo-<1,4>dioxin
Guanoxane
Guanoxon
Guanoxan
debrisoquin

Chemical & Physical Properties

[ Density]:
1.4g/cm3

[ Boiling Point ]:
389.9ºC at 760mmHg

[ Melting Point ]:
164-165°

[ Molecular Formula ]:
C10H13N3O2

[ Molecular Weight ]:
207.22900

[ Flash Point ]:
189.6ºC

[ Exact Mass ]:
207.10100

[ PSA ]:
80.36000

[ LogP ]:
1.50040

[ Vapour Pressure ]:
2.75E-06mmHg at 25°C

[ Index of Refraction ]:
1.639

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ME8510200
CHEMICAL NAME :
Guanidine, (1,4-benzodioxan-2-ylmethyl)-
CAS REGISTRY NUMBER :
2165-19-7
BEILSTEIN REFERENCE NO. :
1251616
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C10-H13-N3-O2
MOLECULAR WEIGHT :
207.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
208 mg/kg/1Y
TOXIC EFFECTS :
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,296,1969

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,4-Benzodioxin-2-methanol, 2,3-dihydro-, 4-methylbenzenesulfonate
  • 2-azidomethyl-2,3-dihydro-1,4-benzodioxine
  • 2,3-Dihydro-1,4-benzodioxin-2-ylmethanol
  • DiBoc guanoxan
  • 1-(2,3-Dihydro-1,4-benzodioxin-2-yl)methanamine

DownStream

Related Compounds

  • Guanoxan-d4
  • DiBoc guanoxan
  • Guanoxan sulfate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 4-Hydroxy-3,5-dimethoxybenzene-1-sulfonyl fluoride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide