6-AZAURIDINE 2',3',5'-TRIACETATE

Suppliers

Names

[ Name ]:
6-AZAURIDINE 2',3',5'-TRIACETATE

[Synonym ]:
EINECS 218-515-6
6-AZURD-TA
6-azauridine-2',3',5'-tri-O-acetate
triacetyl-6-azauridine
ta-azur
cb304
2',3',5'-TRI-O-ACETYL-6-AZAURIDINE
AZARIBINE
2',3',5'-triacetyl-6-azauridine

Chemical & Physical Properties

[ Density]:
1.6g/cm3

[ Melting Point ]:
99-101ºC(lit.)

[ Molecular Formula ]:
C₁₄H₁₇N₃O₉

[ Molecular Weight ]:
371.29900

[ Exact Mass ]:
371.09600

[ PSA ]:
155.88000

[ Index of Refraction ]:
1.621

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XY8577000

CHEMICAL NAME :: as-Triazine-3,5-(2H,4H)-dione, 2-(2',3',5'-triacetyl-beta-D-ribofuranosyl)-

CAS REGISTRY NUMBER :: 2169-64-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C14-H17-N3-O9

MOLECULAR WEIGHT :: 371.34

WISWESSER LINE NOTATION :: T6NNVMVJ B- CT5OTJ BOV1 DOV1 E1OV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 5670 mg/kg/6W

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Blood - changes in cell count (unspecified)

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 108,272,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 321 gm/kg/15W-I

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Blood - changes in erythrocyte (RBC) count Related to Chronic Data - death

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - pig

DOSE/DURATION :: 30 gm/kg/14W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 17,511,1970

Safety Information

[ Safety Phrases ]:
S22-S24/25

[ WGK Germany ]:
2

[ RTECS ]:
XY8577000

Precursor & DownStream

Precursor

DownStream

Related Compounds

6-azauridine 2',3'-O-carbonate
6-S-(4-Chlorophenyl)-6-thio-inosine 2',3',5'-Triacetate
4-Thiouridine 2',3',5'-Triacetate
8-Nitroguanosine 2',3',5'-Triacetate
Inosine, 6-thio-,2',3',5'-triacetate
9H-Purine-6-thiol, 9-b-D-lyxofuranosyl-,2',3',5'-triacetate (8CI)