Etifoxine

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Names

[ Name ]:
Etifoxine

[Synonym ]:
Etifoxine
Etifoxina [Spanish]
4H-3,1-Benzoxazin-2-amine, 6-chloro-N-ethyl-4-methyl-4-phenyl-
6-Chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine
Etifoxina [INN-Spanish]
Etifoxinum [INN-Latin]
Etifoxinum [Latin]
(6-chloro-4-methyl-4-phenyl-4H-benzo[d][1,3]oxazin-2-yl)-ethyl-amine
Etifoxin
rac-etifoxine
Etafenoxine
stresam

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
421.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇ClN₂O

[ Molecular Weight ]:
300.783

[ Flash Point ]:
208.5±31.5 °C

[ Exact Mass ]:
300.102936

[ PSA ]:
33.62000

[ LogP ]:
3.78

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.601

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DM3028000

CHEMICAL NAME :: 4H-3,1-Benzoxazine, 6-chloro-2-ethylamino-4-methyl-4-phenyl-

CAS REGISTRY NUMBER :: 21715-46-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C17-H17-Cl-N2-O

MOLECULAR WEIGHT :: 300.81

WISWESSER LINE NOTATION :: T66 BN DO EHJ CM2 E1 ER& HG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 292 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 55 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1388 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,325,1972

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

Etifoxine-d5
Etifoxine-d3
desethyl-etifoxine
Etifoxine hydrochloride
N-Desethyl etifoxine-d5
N-Desethyl etifoxine--13C,d3
rel-(+)-(1R,2S)-1-(5'-Allyl-2',6-dihydroxy-[1,1'-biphenyl]-3-yl)propane-1,2,3-triol
Eburnamenin-20-one, 14,15-dihydro-14-hydroxy-, (14I+/-)-
(1R,4S)-1,2,3,4-Tetrahydro-7-methoxy-6-methyl-4-(1-methylethyl)-1-naphthalenecarboxylic acid
4,8-Dichloro-5-fluoro-3-nitroquinoline
8-Chloro-5-fluoro-2-methylquinolin-4-ol
[1-(2-chloro-5-fluorophenyl)-1H-1,2,3-triazol-4-yl]methanol
1-[1-(2-chloro-5-fluorophenyl)-1H-1,2,3-triazol-4-yl]ethan-1-ol
1-(2-chloro-5-fluorophenyl)-4-(chloromethyl)-1H-1,2,3-triazole
2-(3-Amino-2,2-dimethylpropyl)phenol
1-(2-chloro-5-fluorophenyl)-1H-1,2,3-triazole-4-carbaldehyde

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