4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol

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Names

[ CAS No. ]:
21928-50-7

[ Name ]:
4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol

[Synonym ]:
4-hydroxy-4-[(4-chloro-3-trifluoromethyl)phenyl]piperidine
Piperidine alcohol
4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidine
4-(p-chloro-m-trifluoromethylphenyl)-4-hydroxypiperidine
4-(4-chloro-3-trifluoromethylphenyl)-4-hydroxypiperidine
4-[4-Chloro-3-(trifluoromethyl)phenyl]-4-piperidinol
4-[4-chlor-3-(trifluormethyl)phenyl]piperidin-4-ol
4-(4-Chloro-3-(trifluoromethyl)phenyl)piperidin-4-ol
4-(4-Chloro-3-(trifluoromethyl)phenyl)-4-piperidinol
4-(3-trifluoromethyl-4-chlorophenyl)-4-hydroxy piperidine
EINECS 244-665-7
MFCD00066999

Chemical & Physical Properties

[ Density]:
1.347 g/cm3

[ Boiling Point ]:
333.3ºC at 760 mmHg

[ Melting Point ]:
138-141 °C(lit.)

[ Molecular Formula ]:
C12H13ClF3NO

[ Molecular Weight ]:
279.68600

[ Flash Point ]:
155.4ºC

[ Exact Mass ]:
279.06400

[ PSA ]:
32.26000

[ LogP ]:
3.25860

[ Vapour Pressure ]:
5.48E-05mmHg at 25°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S22-S24/25-S37/39-S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxy-1-piperidinecarboxylic acid tert-butyl ester

DownStream

  • Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate
  • Penfluridol
  • Fluperamide

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.

Bioorg. Med. Chem. 17 , 3588-3594, (2009)

Direct anti-tuberculosis screening of commercially available compound libraries identified a novel piperidinol with interesting anti-tuberculosis activity and drug like characteristics. To generate a ...

Rhodium catalyzed hydroformylation of 1, 1-bis (p-fluorophenyl) allyl or propargyl alcohol: a key step in the synthesis of Fluspirilen and Penfluridol. Botteghi C, et al.

Tetrahedron 57(8) , 1631-1637, (2001)


More Articles

Related Compounds

  • 2-Fluoro-2-(3-methyl-1-benzofuran-2-yl)ethan-1-amine
  • 5-(2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazol-4-amine
  • tert-butyl N-(1-amino-3,4,4,4-tetrafluorobutan-2-yl)carbamate
  • (1S)-1-(2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-ol
  • 2-[1-(Aminomethyl)-3,3-difluorocyclobutyl]-4-methoxyphenol
  • tert-butyl N-{1-[1-(aminomethyl)-3,3-difluorocyclobutyl]ethyl}-N-methylcarbamate
  • 4-[(oxiran-2-yl)methyl]-1-phenyl-1H-1,2,3-triazole
  • tert-butyl N-{4-[1-(aminomethyl)-2,2-dimethylcyclopropyl]-3-fluorophenyl}carbamate
  • tert-butyl N-[2-(2-bromo-1-hydroxyethyl)-4-fluorophenyl]carbamate
  • tert-butyl N-[4-(1-amino-2-hydroxypropan-2-yl)-2-methoxyphenyl]carbamate
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