NU6027

Suppliers

Names

[ CAS No. ]:
220036-08-8

[ Name ]:
NU6027

[Synonym ]:
6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine
2,6-Diamino-4-cyclohexylmethoxy-5-nitroso pyrimidine
NU6027
NW1
1e1x
6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE
2,4-Pyrimidinediamine, 6-(cyclohexylmethoxy)-5-nitroso-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
549.2±60.0 °C at 760 mmHg

[ Melting Point ]:
252.5-253.7 °C(lit.)

[ Molecular Formula ]:
C₁₁H₁₇N₅O₂

[ Molecular Weight ]:
251.285

[ Flash Point ]:
286.0±32.9 °C

[ Exact Mass ]:
251.138229

[ PSA ]:
117.21000

[ LogP ]:
3.71

[ Appearance of Characters ]:
lavender

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 15 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.

PLoS ONE 8 , e57098, (2013)

Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repai...

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.

Br. J. Cancer 105 , 372-81, (2011)

The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been ...

Kinetically-defined component actions in gene repression.

PLoS Comput. Biol. 11(3) , e1004122, (2015)

Gene repression by transcription factors, and glucocorticoid receptors (GR) in particular, is a critical, but poorly understood, physiological response. Among the many unresolved questions is the diff...

4-(4-fluorobenzyl)-1-[3-oxo-3-(4-phenylpiperazin-1-yl)propyl][1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one
Methyl 2-(3,5-dimethoxyphenyl)-1H-pyrrole-3-carboxylate
3-(benzenesulfonyl)-N-(4-fluorophenyl)-6-methoxyquinolin-4-amine
N-[4-(4-methylphenyl)phenyl]methanesulfonamide
6-ethoxy-N-(4-fluorophenyl)-3-tosylquinolin-4-amine
(2-(4-methoxyphenyl)-9-methyl-4-((4-methylbenzyl)thio)-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-6-yl)methanol
(7-{[(4-Fluorophenyl)methyl]sulfanyl}-5-(3-methoxyphenyl)-14-methyl-2-oxa-4,6,13-triazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),3(8),4,6,11,13-hexaen-11-yl)methanol
(2-(3-chlorophenyl)-4-((4-fluorobenzyl)thio)-9-methyl-5H-pyrido[4',3':5,6]pyrano[2,3-d]pyrimidin-6-yl)methanol
2-{[11-(hydroxymethyl)-14-methyl-5-(3-methylphenyl)-2-oxa-4,6,13-triazatricyclo[8.4.0.0^{3,8}]tetradeca-1(10),3(8),4,6,11,13-hexaen-7-yl]sulfanyl}-N-methyl-N-phenylacetamide
N-benzyl-3-((4-ethylphenyl)sulfonyl)-N-methylthieno[2,3-e][1,2,3]triazolo[1,5-a]pyrimidin-5-amine

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