NU6027

Suppliers

Names

[ CAS No. ]:
220036-08-8

[ Name ]:
NU6027

[Synonym ]:
6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine
2,6-Diamino-4-cyclohexylmethoxy-5-nitroso pyrimidine
NU6027
NW1
1e1x
6-CYCLOHEXYLMETHYLOXY-5-NITROSO-PYRIMIDINE-2,4-DIAMINE
2,4-Pyrimidinediamine, 6-(cyclohexylmethoxy)-5-nitroso-

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
549.2±60.0 °C at 760 mmHg

[ Melting Point ]:
252.5-253.7 °C(lit.)

[ Molecular Formula ]:
C11H17N5O2

[ Molecular Weight ]:
251.285

[ Flash Point ]:
286.0±32.9 °C

[ Exact Mass ]:
251.138229

[ PSA ]:
117.21000

[ LogP ]:
3.71

[ Appearance of Characters ]:
lavender

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.699

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: 15 mg/mL

MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cells.

PLoS ONE 8 , e57098, (2013)

Ataxia telangiectasia mutated and Rad3 Related (ATR) protein kinase is a key sensor of single-stranded DNA associated with stalled replication forks and repair intermediates generated during DNA repai...

Identification and evaluation of a potent novel ATR inhibitor, NU6027, in breast and ovarian cancer cell lines.

Br. J. Cancer 105 , 372-81, (2011)

The ataxia telangiectasia mutated and Rad3-related kinase (ATR) has a key role in the signalling of stalled replication forks and DNA damage to cell cycle checkpoints and DNA repair. It has long been ...

Kinetically-defined component actions in gene repression.

PLoS Comput. Biol. 11(3) , e1004122, (2015)

Gene repression by transcription factors, and glucocorticoid receptors (GR) in particular, is a critical, but poorly understood, physiological response. Among the many unresolved questions is the diff...


More Articles


Related Compounds

  • 2-methoxy-3-(1H-pyrazol-4-yl)pyridine
  • 7-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)thio)heptanoic acid
  • tert-butyl (2S,3R)-2-(benzylamino)-3-hydroxybutanoate
  • Alanosyl-aicor
  • 2-(3-Azidopropyl)-1,3-benzothiazole
  • Butanoic acid, 9H-fluoren-9-yl ester
  • 2,4-Bis(1-methylethoxy)thieno[3,2-d]pyrimidine
  • 1-acetyl-6-methyl-3-Piperidinecarbonitrile
  • (S)-4-(Methoxymethyl)oxazolidine-2,5-dione
  • 12H-Benzo[b]phenoxazine-12-propanenitrile
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