TRO 19622

Names

[ CAS No. ]:
22033-87-0

[ Name ]:
TRO 19622

[Synonym ]:
Cholest-4-en-3-on-oxim
3-oxyimino-cholest-4-ene
olesoxime
TRO 19622

Chemical & Physical Properties

[ Density]:
1.1

[ Boiling Point ]:
510ºC at 760mmHg

[ Melting Point ]:
145-148ºC

[ Molecular Formula ]:
C₂₇H₄₅NO

[ Molecular Weight ]:
399.65200

[ Flash Point ]:
341ºC

[ Exact Mass ]:
399.35000

[ PSA ]:
32.59000

[ LogP ]:
7.85800

[ Vapour Pressure ]:
1.56E-12mmHg at 25°C

[ Index of Refraction ]:
1.583

[ Storage condition ]:
−20°C

MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.

J. Pharmacol. Exp. Ther. 322 , 709-720, (2007)

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a ce...

The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation.

J. Neurosci. 31(1) , 359-70, (2011)

Ablation of mouse occipital cortex induces precisely timed and uniform p53-modulated and Bax-dependent apoptosis of thalamocortical projection neurons in the dorsal lateral geniculate nucleus (LGN) by...

Specific antinociceptive activity of cholest-4-en-3-one, oxime (TRO19622) in experimental models of painful diabetic and chemotherapy-induced neuropathy.

J. Pharmacol. Exp. Ther. 326(2) , 623-32, (2008)

Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy an...