GW5074

[ Density]:
2.2±0.1 g/cm3

[ Boiling Point ]:
561.4±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₈Br₂INO₂

[ Molecular Weight ]:
520.942

[ Flash Point ]:
293.3±30.1 °C

[ Exact Mass ]:
518.796631

[ PSA ]:
49.33000

[ LogP ]:
6.36

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.790

[ Storage condition ]:
-20°C

[ Water Solubility ]:
DMSO: soluble

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Rotenone inhibits primary murine myotube formation via Raf-1 and ROCK2.

Biochim. Biophys. Acta 1853 , 1606-14, (2015)

Rotenone (ROT) is a widely used inhibitor of complex I (CI), the first complex of the mitochondrial oxidative phosphorylation (OXPHOS) system. However, particularly at high concentrations ROT was also...

Antibody-opsonized bacteria evoke an inflammatory dendritic cell phenotype and polyfunctional Th cells by cross-talk between TLRs and FcRs.

J. Immunol. 194(4) , 1856-66, (2015)

During secondary immune responses, Ab-opsonized bacteria are efficiently taken up via FcRs by dendritic cells. We now demonstrate that this process induces cross-talk between FcRs and TLRs, which resu...

Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.

Hum. Mol. Genet. 23(23) , 6212-22, (2014)

Mutations in the leucine-rich repeat kinase-2 (LRRK2) gene cause autosomal-dominant Parkinson's disease (PD) and contribute to sporadic PD. LRRK2 contains Guanosine-5'-triphosphate (GTP) binding, GTPa...

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