2,3-Dichloroquinoxaline

Suppliers

Names

[ Name ]:
2,3-Dichloroquinoxaline

[Synonym ]:
2,3-Dichloroquinoxaline
2,3-DICHLORO-QUINOXALINE
2,3,6-TRIFLUOROBENZOICACID
2,3-dichloroquinoxazoline
2,3-dichloroquinaxoline
Quinoxaline,2,3-dichloro
Quinoxaline, 2,3-dichloro-
EINECS 218-667-3
MFCD00006720
2,3-dichloro quinoxaline

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
269.7±35.0 °C at 760 mmHg

[ Melting Point ]:
152-154 °C(lit.)

[ Molecular Formula ]:
C₈H₄Cl₂N₂

[ Molecular Weight ]:
199.037

[ Flash Point ]:
142.9±11.5 °C

[ Exact Mass ]:
197.975159

[ PSA ]:
25.78000

[ LogP ]:
3.04

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.671

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VD1720000

CHEMICAL NAME :: Quinoxaline, 2,3-dichloro-

CAS REGISTRY NUMBER :: 2213-63-0

BEILSTEIN REFERENCE NO. :: 0126076

LAST UPDATED :: 199806

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H4-Cl2-N2

MOLECULAR WEIGHT :: 199.04

WISWESSER LINE NOTATION :: T66 BN ENJ CG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 195 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Gastrointestinal - peritonitis Kidney, Ureter, Bladder - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534573

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03256

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R25;R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S45-S37/39-S28A

[ RIDADR ]:
2811

[ WGK Germany ]:
3

[ RTECS ]:
VD1720000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Precursor & DownStream

Precursor

DHQ
3-chloro-1H-quinoxalin-2-one
2-chloro-3-nitroquinoxaline
o-Phenylenediamine
2(1H)-Quinoxalinone
Quinoxaline
1-benzyl-1,4-dihydro-quinoxaline-2,3-dione
2(1H)-Quinoxalinone,4-oxide
3-Chloro-2-quinoxalinamine
N-Benzyl-1,2-benzenediamine

DownStream

1-chloro-12H-quinoxalino[2,3-b][1,4]benzothiazine
2-Benzyl-3-chloroquinoxaline
3-Chloro-2-quinoxalinamine
2-Quinoxalinamine,3-methoxy-
3-ethoxyquinoxalin-2-amine
N-(3-Chloroquinoxalin-2-yl)-4-methylbenzenesulfonamide
2-Chloro-3-methoxyquinoxaline
4-Chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline
2,2'-Biquinoxaline

Articles

Synthesis of some new pyrimido[2',1':2,3]thiazolo[4,5-b]quinoxaline derivatives as anti-inflammatory and analgesic agents.

Eur. J. Med. Chem. 45 , 1976-81, (2010)

Treatment of 6-aminothiouracil (1) with 2,3-dichloroquinoxaline (2) in ethanol/TEA afforded 6-amino-2-(3-chloroquinoxalin-2-ylthio)pyrimidin-4(3H)-one (3), which was refluxed in DMF to give 2-aminopyr...

Synthesis, structure elucidation and antibacterial evaluation of new steroidal -5-en-7-thiazoloquinoxaline derivatives.

Eur. J. Med. Chem. 43 , 2257-61, (2008)

Some heterocyclic systems namely cholest-5-en-7-thiazolo[4,5-b]quinoxaline-2-yl-hydrazone] were synthesized by the reaction of cholest-5-en-7-one-thiosemicarbazone with 2,3-dichloroquinoxaline at 80 d...

AlCl3 induced (hetero)arylation of 2,3-dichloroquinoxaline: a one-pot synthesis of mono/disubstituted quinoxalines as potential antitubercular agents.

Bioorg. Med. Chem. 20(5) , 1711-22, (2012)

A direct and single-step method has been developed for the synthesis of mono and 2,3-disubstituted quinoxalines by using a AlCl(3) induced (hetero)arylation of 2,3-dichloroquinoxaline. Both symmetrica...