Rupintrivir

Suppliers

Names

[ CAS No. ]:
223537-30-2

[ Name ]:
Rupintrivir

[Synonym ]:
ag7088
UNII-RGE5K1Q5QW
Ruprintrivir
Rupintrivir

Chemical & Physical Properties

[ Density]:
1.213g/cm3

[ Boiling Point ]:
866.7ºC at 760mmHg

[ Melting Point ]:
170-171°C

[ Molecular Formula ]:
C₃₁H₃₉FN₄O₇

[ Molecular Weight ]:
598.66200

[ Flash Point ]:
477.9ºC

[ Exact Mass ]:
598.28000

[ PSA ]:
156.70000

[ LogP ]:
3.93550

[ Vapour Pressure ]:
1.87E-30mmHg at 25°C

[ Index of Refraction ]:
1.537

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Articles

Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues.

J. Virol. 85(19) , 10021-30, (2011)

EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent a...

Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

Antimicrob. Agents Chemother. 49(2) , 619-26, (2005)

The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV)...