Triflubazam

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Names

[ CAS No. ]:
22365-40-8

[ Name ]:
Triflubazam

[Synonym ]:
Triflubazam
7-trifluoromethyl-1-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-2,4-dione
Triflubazam [USAN:INN]
1-methyl-5-phenyl-7-trifluoromethyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione
Triflubazamum [INN-Latin]
WE 352
ORF-8063
1-Methyl-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione

Chemical & Physical Properties

[ Density]:
1.354g/cm3

[ Boiling Point ]:
599.9ºC at 760mmHg

[ Molecular Formula ]:
C17H13F3N2O2

[ Molecular Weight ]:
334.29300

[ Flash Point ]:
316.6ºC

[ Exact Mass ]:
334.09300

[ PSA ]:
40.62000

[ LogP ]:
3.86660

[ Vapour Pressure ]:
2.38E-14mmHg at 25°C

[ Index of Refraction ]:
1.561

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE9610000
CHEMICAL NAME :
1H-1,5-Benzodiazepine-2,4-(3H,5H)-dione, 1-methyl-5-phenyl-7-trifluoromethyl-
CAS REGISTRY NUMBER :
22365-40-8
BEILSTEIN REFERENCE NO. :
0765367
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H13-F3-N2-O2
MOLECULAR WEIGHT :
334.32
WISWESSER LINE NOTATION :
T67 GNV JVN IHJ CXFFF G1 KR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTCEA9 Current Therapeutic Research, Clinical & Experimental. (Therapeutic Research Press, Inc., POB 514, Tenafly, NJ 07670) V.1- 1959- Volume(issue)/page/year: 16,1022,1974

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • n-methyl-2-nitro-4-(trifluoromethyl)aniline
  • N1-Methyl-4-(Trifluoromethyl)Benzene-1,2-Diamine
  • Triphenylbismuth
  • 1-methyl-7-(trifluoromethyl)-5H-1,5-benzodiazepine-2,4-dione

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-Chloro-4-(ethoxycarbonyl)-1-methyl-1H-pyrazole 2-oxide
  • 3-Chloro-8-((triisopropylsilyl)ethynyl)naphthalen-1-ol
  • Methyl (2R)-2-fluorotetrahydro-1H-pyrrolizine-7a(5H)-carboxylate
  • Ethyl 1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxylate
  • 1-(2-Azidoethyl)-3-chloro-5-(trifluoromethyl)benzene
  • 1-(tert-Butyl) 2-methyl (4R)-2-(3-chloropropyl)-4-fluoropyrrolidine-1,2-dicarboxylate
  • 1-Benzyl-2-(((tert-butyldimethylsilyl)oxy)methyl)-3-methoxy-2-methylazetidine
  • tert-Butyl (1R,5R,7S)-7-methyl-2,6-diazabicyclo[3.2.0]heptane-2-carboxylate
  • ((8-Bromo-6-(methoxymethoxy)naphthalen-1-yl)ethynyl)triisopropylsilane
  • 2-(4-amino-3-methyl-1H-pyrazol-1-yl)-N-tert-butylacetamide
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