BIS(7)-TACRINE

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Names

[ CAS No. ]:
224445-12-9

[ Name ]:
BIS(7)-TACRINE

[Synonym ]:
N,N'-Di(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine dihydrochloride
9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride
Tacrine-Based Inhibitor 2f
heptylene-bis(tacrine) dihydrochloride heptylene-bis(THA) dihydrochloride
1,7-Heptanediamine, N,N-bis(1,2,3,4-tetrahydro-9-acridinyl)-, hydrochloride (1:2)

Chemical & Physical Properties

[ Molecular Formula ]:
C33H42Cl2N4

[ Molecular Weight ]:
565.619

[ Exact Mass ]:
564.278625

[ PSA ]:
49.84000

[ LogP ]:
9.76510

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
25-36/37/38

[ Safety Phrases ]:
26-36-45

[ RIDADR ]:
UN 2811 6.1/PG 3

Articles

Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. Pang, et al.

J. Chem. Soc. Perkin Trans. I , 171, (1997)

Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.

J. Biol. Chem. 271 , 23646, (1996)

We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand doc...


More Articles


Related Compounds

  • bis(7-methyloctoxy)-oxophosphanium,potassium
  • bis(7-oxo-2H-triazolo[4,5-d]pyrimidin-3-yl)mercury,tetrahydrate
  • bis(7-oxofuro[3,2-g]chromen-9-yl) heptanedioate
  • bis(7-methyloctyl) nonanedioate
  • bis(7-methyloctyl) (Z)-but-2-enedioate
  • Bis(7-methyloctyl) 1,2-(2H4)benzenedicarboxylate
  • (1S)-2-amino-1-(4-chloro-2-methylphenyl)ethan-1-ol
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • N-(2-hydroxy-2-(thiophen-2-yl)-2-(thiophen-3-yl)ethyl)-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 2-(2-chloro-6-fluorophenyl)-N-((3-(6-ethoxypyridin-3-yl)-1,2,4-oxadiazol-5-yl)methyl)acetamide
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4-Phenyl-1-(6-((tetrahydrothiophen-3-yl)oxy)nicotinoyl)piperidine-4-carbonitrile