BIS(7)-TACRINE

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Names

[ Name ]:
BIS(7)-TACRINE

[Synonym ]:
N,N'-Di(1,2,3,4-tetrahydro-9-acridinyl)-1,7-heptanediamine dihydrochloride
9-Amino-1,2,3,4-tetrahydroacridine bis 1,7-heptylene dihydrochloride
Tacrine-Based Inhibitor 2f
heptylene-bis(tacrine) dihydrochloride heptylene-bis(THA) dihydrochloride
1,7-Heptanediamine, N,N-bis(1,2,3,4-tetrahydro-9-acridinyl)-, hydrochloride (1:2)

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₃H₄₂Cl₂N₄

[ Molecular Weight ]:
565.619

[ Exact Mass ]:
564.278625

[ PSA ]:
49.84000

[ LogP ]:
9.76510

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
25-36/37/38

[ Safety Phrases ]:
26-36-45

[ RIDADR ]:
UN 2811 6.1/PG 3

Articles

Synthesis of alkylene linked bis-THA and linked benzyl-THA as highly potent and selective inhibitors and molecular probes of acetylcholinesterase. Pang, et al.

J. Chem. Soc. Perkin Trans. I , 171, (1997)

Highly potent, selective, and low cost bis-tetrahydroaminacrine inhibitors of acetylcholinesterase. Steps toward novel drugs for treating Alzheimer's disease.

J. Biol. Chem. 271 , 23646, (1996)

We report highly potent, selective, and low cost bifunctional acetylcholinesterase (AChE) inhibitors developed by our two-step prototype optimization strategy utilizing computer modeling of ligand doc...

bis(7-methyloctoxy)-oxophosphanium,potassium
bis(7-oxo-2H-triazolo[4,5-d]pyrimidin-3-yl)mercury,tetrahydrate
bis(7-oxofuro[3,2-g]chromen-9-yl) heptanedioate
bis(7-methyloctyl) nonanedioate
bis(7-methyloctyl) (Z)-but-2-enedioate
Bis(7-methyloctyl) 1,2-(2H4)benzenedicarboxylate
Methyl 6-tert-butylpiperidine-2-carboxylate
Tert-butyl 6-[(2-methylpropan-2-yl)oxycarbonyloxy]cyclohexene-1-carboxylate
(R)-3-((tert-Butoxycarbonyl)amino)-4-methoxybutanoic acid
4-(1-Benzyl-1H-pyrazol-4-yl)-4-oxobutanoic acid
1-[(tert-Butyldimethylsilyl)oxy]-1-cyclopropylbut-3-en-2-one
1-Chloro-3-(2-fluoro-4-iodophenyl)propan-2-one
rac-(1R,2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopropane-1-carboxylic acid
Methyl 6-cyclobutylpyridine-3-carboxylate
3-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]thiophene-2-carboxylic acid
4-({[(tert-butoxy)carbonyl]amino}methyl)-1-methyl-1H-1,2,3-triazole-5-carboxylic acid

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