Hydroxocobalamin Acetate

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Names

[ CAS No. ]:
22465-48-1

[ Name ]:
Hydroxocobalamin Acetate

[Synonym ]:
Hydroxocobalamin acetate
Vitamin B12a acetate
HYDROXOCOBALAMIN ACETATE

Chemical & Physical Properties

[ Melting Point ]:
>300ºC.

[ Molecular Formula ]:
C64H91CoN13O16P

[ Molecular Weight ]:
1388.39000

[ Exact Mass ]:
1387.58000

[ PSA ]:
490.17000

[ LogP ]:
6.62930

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GG3740000
CHEMICAL NAME :
Cobinamide, acetate (salt) hydroxide, dihydrogen phosphate (ester), inner salt, 3'-ester with 5,6-dimethyl-1-alpha-D-ribofuranosylbenzimidazole
CAS REGISTRY NUMBER :
22465-48-1
LAST UPDATED :
199409
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C64-H91-Co-N13-O16-P
MOLECULAR WEIGHT :
1388.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,622,1982

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P280

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
GG3740000

Articles

Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.

Mol. Genet. Metab. 97 , 260-266, (2009)

The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that the c...

Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.

Chem. Soc. Rev. 40 , 4346-4363, (2011)

B(12)-cofactors play important roles in the metabolism of microorganisms, animals and humans. Microorganisms are the only natural sources of B(12)-derivatives, and the latter are "vitamins" for other ...

B12 trafficking in mammals: A for coenzyme escort service.

ACS Chem. Biol. 1 , 149-159, (2006)

Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the c...


More Articles


Related Compounds

  • Hydroxocobalamin
  • chrysanthenyl acetate
  • Glutinol acetate
  • Menthyl acetate
  • isoprenyl acetate
  • Germanicol acetate
  • (2R)-2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-(4-methylphenyl)acetamido]butanoic acid
  • 1-[5-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-methylpentanoyl]-3-methylpiperidine-2-carboxylic acid
  • 1-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclohexyl]acetyl}pyrrolidine-3-carboxylic acid
  • 4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-{[(1-methoxycyclopentyl)methyl]carbamoyl}butanoic acid
  • 1-{2-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido]-N-methylacetamido}cyclobutane-1-carboxylic acid
  • 2-[N-ethyl-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pent-4-ynamido]acetic acid
  • 3-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4,4-dimethylpentanamido]hexanoic acid
  • 2-{4-[3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-methylpentanoyl]piperazin-1-yl}acetic acid
  • 3-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3,3-trifluoro-2-methylpropanamido]hexanoic acid
  • 2-(1-{2-[1-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)cyclopentyl]acetyl}azetidin-3-yl)propanoic acid
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