3,3-Dimethylpiperazin-2-on

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Names

[ CAS No. ]:
22476-74-0

[ Name ]:
3,3-Dimethylpiperazin-2-on

[Synonym ]:
3,3-dimethylpiperazine-2-one
Dimethyl-3,3 oxo-2 piperazine [French]
3,3-Dimethyl-2-piperazinone
3,3-dimethyl-piperazinone
2-Piperazinone,3,3-dimethyl
3,3-di-methylpiperazin-2-one
2,2-dimethyl-3-oxopiperazine
2-Piperazinone, 3,3-dimethyl-
3,3-Dimethylpiperazin-2-on
3,3-dimethylpiperazin-2-one

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
275.0±33.0 °C at 760 mmHg

[ Molecular Formula ]:
C6H12N2O

[ Molecular Weight ]:
128.172

[ Flash Point ]:
132.5±25.5 °C

[ Exact Mass ]:
128.094955

[ PSA ]:
41.13000

[ LogP ]:
-1.16

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.432

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TM3407956
CHEMICAL NAME :
2-Piperazinone, 3,3-dimethyl-
CAS REGISTRY NUMBER :
22476-74-0
BEILSTEIN REFERENCE NO. :
0112353
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C6-H12-N2-O
MOLECULAR WEIGHT :
128.20

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CHTPBA Chimica Therapeutica. (Paris, France) V.1-8, 1965-73. For publisher information, see EJMCA5. Volume(issue)/page/year: 4,167,1969

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl 2-bromoisobutyrate
  • 1,2-Ethanediamine
  • Acetone cyanohydrin
  • Ethanol

DownStream

  • Piperazinone, 4-(2-hydroxyethyl)-3,3-dimethyl- (8CI,9CI)
  • 2,2-Dimethylpiperazine
  • Piperazinone, 4-(3-hydroxypropyl)-3,3-dimethyl- (9CI)
  • 1-Piperazinecarboxaldehyde,2,2-dimethyl-3-oxo-(9CI)
  • Piperazinone, 4-(chloroacetyl)-3,3-dimethyl- (9CI)
  • 1,4-dibenzyl-2,2-dimethyl-piperazine

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 4-(2-hydroxyethyl)-3,3-dimethylpiperazin-2-one
  • 3,3-Dimethyl-1-zinntributyl-butan-2-on
  • 3-[(3,4-diethoxyphenyl)methyl]-3,4-dimethylpiperazin-2-one
  • 3,3-Bis(3-methyl-4-hydroxyphenyl)indoline-2-on
  • 3-[3-(2-cyanoethyl)-6,6-dimethyl-4-oxooxan-3-yl]propanenitrile
  • 3,3-dimethyl-2H-pyran-6-one
  • 3-({[(9H-fluoren-9-yl)methoxy]carbonyl}(3-nitropyridin-2-yl)amino)propanoic acid
  • 5-{3H,4H,5H,6H,7H-imidazo[4,5-c]pyridin-4-yl}-3-methoxy-1,2-thiazole
  • tert-butyl 6,7-dihydro-5H-spiro[furo[3,2-c]pyridine-4,3'-piperidine]-1'-carboxylate
  • 4-(Cyclopropylmethyl)-1-ethyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
  • 1-(Cyclopropylmethyl)-4-methyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid
  • 3-Benzyl-5-bromo-6-(cyclopropylmethyl)-3,4-dihydropyrimidin-4-one
  • 5-Bromo-3-(2-methoxyethyl)-6-(pyridin-2-yl)-3,4-dihydropyrimidin-4-one
  • 2-(3,3-Difluorocyclobutyl)-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-ol
  • 7-Tert-butyl-2-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-5-ol
  • 2-(Azetidin-3-yl)-6-ethyl-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-5-ol