BENZ(C)ACRIDINE

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Names

[ CAS No. ]:
225-51-4

[ Name ]:
BENZ(C)ACRIDINE

[Synonym ]:
3,4-Benzacridine
Benzo[c]acridine
3,4-Benzoacridine
BENZ(C)ACRIDINE
12-Azabenz[a]anthracene
Benz[c]acridine
7,8-Benzacridine

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
446.2±14.0 °C at 760 mmHg

[ Melting Point ]:
132°C

[ Molecular Formula ]:
C17H11N

[ Molecular Weight ]:
229.276

[ Flash Point ]:
201.4±12.7 °C

[ Exact Mass ]:
229.089142

[ PSA ]:
12.89000

[ LogP ]:
4.63

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.783

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CU2975000
CHEMICAL NAME :
Benz(c)acridine
CAS REGISTRY NUMBER :
225-51-4
BEILSTEIN REFERENCE NO. :
0154999
LAST UPDATED :
199612
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H11-N
MOLECULAR WEIGHT :
229.29
WISWESSER LINE NOTATION :
T D6 B666 CNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 mg/kg/67W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9630 mg/kg/3D-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,103,1983 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 32,129,1983 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987

Safety Information

[ RIDADR ]:
UN 2811

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-phenylquinoline-3-carbaldehyde
  • Benzenamine, N-[(2-fluorophenyl)methylene]-2,6-dimethyl- (9CI)
  • 2-Fluorobenzaldehyde
  • 1,4,7,12-Tetrahydrobenz[c]acridine
  • 1-Bromonaphthalene
  • Formylaniline
  • 1,2,3,4,7,12-Hexahydrobenz[c]acridine
  • Silver acetate
  • ethyl (2-chloropyridin-3-yl)carbamate

DownStream

  • 3,4-dihydrobenzo[c]acridine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons.

Bioorg. Med. Chem. 8(5) , 1171-82, (2000)

Coralyne and several other synthetic benzo[a,g]quinolizium derivatives related to protoberberine alkaloids have exhibited activity as topoisomerase poisons. These compounds are characterized by the pr...

Heteroatom effects in chemical carcinogenesis: effects of ring heteroatoms on ease of carbocation formation.

Cancer Biochem. Biophys. 7(1) , 53-60, (1983)

The presence of a heteroatom can influence the ease with which a PAH diol-epoxide forms a triol carbocation. The influence of the heteroatom should be greatest when it is located where the PAH undergo...

Differentiated genotoxic response of carcinogenic and non-carcinogenic benzacridines and metabolites in rat hepatoma cells.

Carcinogenesis 6(3) , 455-7, (1985)

Two closely related hepatoma cell lines were examined for their genotoxic response to benacridines and their metabolites by the appearance of alkaline labile DNA sites: H5, a dedifferentiated line exp...


More Articles

Related Compounds

  • Benz[c]acridine
  • benz(a)acridine
  • 7-Ethylbenz(c)acridine
  • 5-METHYLBENZ(C)ACRIDINE
  • 8-Methylbenz(c)acridine
  • 3-methoxybenzo[c]acridine
  • N-(4-(furan-2-yl)thiazol-2-yl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
  • N-(4-(N-(4-methylpyrimidin-2-yl)sulfamoyl)phenyl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
  • N-(2,3-dichlorophenyl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
  • (3-(1H-tetrazol-1-yl)phenyl)(4-(2-(2-phenyl-1H-imidazol-1-yl)ethyl)piperazin-1-yl)methanone
  • 1-phenyl-4-(4-(2-(2-phenyl-1H-imidazol-1-yl)ethyl)piperazin-1-yl)butane-1,4-dione
  • N-(2-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)ethyl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
  • 3-(phenylthio)-N-((5-(thiophen-3-yl)pyridin-3-yl)methyl)propanamide
  • N-(2-(4-acetamidobenzamido)ethyl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
  • N-(2-(3-(3,5-dimethyl-1H-pyrazol-1-yl)-6-oxopyridazin-1(6H)-yl)ethyl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
  • N-(2-phenylimidazo[1,2-a]pyridin-3-yl)-6-(pyrrolidin-1-yl)pyridazine-3-carboxamide
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